Results 81 to 90 of about 3,876,747 (291)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Vibration reduction optimisation design of the high‐speed elevator car system based on multi‐factor horizontal coupling vibration model

open access: yesIET Collaborative Intelligent Manufacturing
The increasing need for safe and comfortable high‐speed elevators due to the rise of super‐tall buildings has led to a focus on vibration reduction modelling and optimisation.
Meihao Chen   +5 more
doaj   +1 more source

Altitude Control in an Unmanned Aerial Vehicle Through Deflection of Elevator

open access: yesEngineering Proceedings
This paper investigates altitude control of the Unmanned Aerial Vehicle (UAV) through the elevator. Elevators are flight control surfaces, which control lateral altitude by changing the pitch balance.
Muhammad Hashier Muneeb Farrukh   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Multi-Objective optimization for stable and efficient cargo transportation of partial space elevator

open access: yesDefence Technology
This paper proposed a new libration decoupling analytical speed function (LD-ASF) in lieu of the classic analytical speed function to control the climber's speed along a partial space elevator to improve libration stability in cargo transportation.
Gefei Shi, Zheng H. Zhu
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Atom interferometry in an Einstein Elevator

open access: yesNature Communications
Recent advances in atom interferometry have led to the development of quantum inertial sensors with outstanding performance in terms of sensitivity, accuracy, and long-term stability. For ground-based implementations, these sensors are ultimately limited
C. Pelluet   +7 more
doaj   +1 more source

Difference distance map data of alternative crystal forms of UlaA

open access: yesData in Brief, 2017
We introduce the value of information obtained by comparing alternative crystal forms of the same sub-state (of outward open UlaA, our example protein), which is found in the same lattice configuration but different space groups.
Ake Vastermark   +5 more
doaj   +1 more source

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