Results 91 to 100 of about 3,876,747 (291)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Tethered Elevator Design For Space Station
, 1992 This paper describes the conceptual engineering design of a space station elevator that operates on a 10-km tether spanning the distance between the space station and a tethered platform.
Anderson, Loren A., Haddock, Michael H.
core +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2008 A space elevator is a tall structure that starts from the surface of the Earth and reaches out beyond geostationary orbit (GEO) in space. The space elevator could be used to deliver payloads to any Earth’s orbit or send them to any other planet in the ...
Kaithi, Vijaya
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BuildingsAs China’s dominant urban housing form, gated residential communities deploy layered spatial access controls governing who may enter and move through neighbourhood space.
Yi Li +6 more
doaj +1 more source
Minnesota Cooperative Elevator Associations
, 1951 36 pagesTHE FARMERS' elevator movement in Minnesota started about 1890. The number of elevator associations in which farmers owned at least 50 per cent of the stock had grown to 270 by 1914.
Cox, Rex W.
core
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
AerospaceA partial space elevator (PSE) is a multi-body tethered space system in which the main satellite, typically an ultra-large spacecraft or a space station in a higher orbit, is connected to a transport spacecraft in a lower orbit via a tether, maintaining ...
Weili Xu, Xuerong Yang, Gefei Shi
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The Physics of a Space Elevator [PDF]
, 2014 A space elevator is a hypothetical device consisting of a long cable attached to the surface of the earth that extends upward into space. Its purpose is to provide a tether on which a vehicle could be lifted up into orbit, greatly reducing the cost of ...
Hamer, Trevor
core +1 more source