Results 101 to 110 of about 1,638,848 (302)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

The challenges and benefits of lunar exploration [PDF]

Three decades into the Space Age, the United States is experiencing a fundamental shift in space policy with the adoption of a broad national goal to expand human presence and activity beyond Earth orbit and out into the Solar System.
Cohen, Aaron
core   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

Geological characteristics of Chang’E-6 landing area in micro-scale unveiled by new observation data

Nature Communications
Chang’E-6 mission successfully achieved humanity’s first sample return from the farside of the Moon. Here, we report a high-precision terrain dataset with millimeter-to-decimeter spatial resolution around the CE-6 landing site. Based on this dataset, the
Wei Yan, Xingguo Zeng, Xin Ren, Wangli Chen, Xingye Gao, Wei Zuo, Bin Liu, Zhoubin Zhang, Qiang Fu, Jianjun Liu, Chunlai Li   +10 more
doaj   +1 more source

Symbiotic CPS Design-Space Exploration through Iterated Optimization [PDF]

, 2023
Sheng-Jung Yu, Inigo Incer, Valmik Prabhu, Anwesha Chattoraj, Eric Vin, Daniel J. Fremont, Ankur Mehta, Alberto Sangiovanni‐Vincentelli, S. Shankar Sastry, Sanjit A. Seshia   +9 more
openalex   +1 more source

Halley's comet 1985-86: space exploration [PDF]

A coordinated program to explore Halley's comet in 1985 to 86 is proposed. The program employs a variety of observational systems for remote observations and utilizes spacecraft encounters with the comet to obtain in-situ measurements.
Farquhar, R. W., Wooden, W. H., II
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Biostatistics of Space Exploration - Microbiology and Sterilization [PDF]

Contamination probability distribution models for spacecraft - microbiological assays and sterilization of spacecraft ...
Cornell, R. G.
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source