Results 81 to 90 of about 5,105,031 (285)

Design and Analysis of a Micro–Electro-Mechanical System Thruster for Small Satellites and Low-Thrust Propulsion

Aerospace
As a cost-effective and versatile solution, small satellites are increasingly being considered for space exploration. However, one of the major challenges in deploying small satellites for high total impulse missions, particularly deep space exploration,
Yubin Zhong, Fabrizio Ponti, Francesco Barato, Guojun Xia, Siyu Li, Xiao Zhang, Tao Wu   +6 more
doaj   +1 more source

Effect of Tilted Misalignment on Tribo-Characteristics of High-Speed Ball Bearings in Liquid Hydrogen

Tribology Online, 2010
When radial load applied to the bearings was high, ball excursion occurring in the retainer ball-pockets became large due to ball-speed-variation (BSV). Such BSV was also caused by inclination of the outer race to the shaft (tilted misalignment).
Masataka Nosaka, Satoshi Takada, Makoto Yoshida, Masataka Kikuchi, Takayuki Sudo, Shohei Nakamura   +5 more
doaj   +1 more source

High Altitude Skydiving Apparatus

, 2022
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Descent trajectory reconstruction and landing site positioning of Chang’E-4 on the lunar farside

Nature Communications, 2019
The Chang’E-4 mission in January 2019 had the major challenge to land on the lunar far side without traditional radiometric techniques due to the missing line-of-sight.
Jianjun Liu, Xin Ren, Wei Yan, Chunlai Li, He Zhang, Yang Jia, Xingguo Zeng, Wangli Chen, Xingye Gao, Dawei Liu, Xu Tan, Xiaoxia Zhang, Tao Ni, Hongbo Zhang, Wei Zuo, Yan Su, Weibin Wen   +16 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impact Study of Assimilating Fengyun-3 GNSS-R Ocean Surface Winds in the Weather Research and Forecasting Model: Sensitivity Analysis on Observation Error Specifications

Remote Sensing
The Global Navigation Satellite System Reflectometry (GNSS-R) technique provides global ocean surface wind observations unaffected by rainfall with high spatiotemporal resolution.
Guanyi Wang, Weihua Bai, Feixiong Huang, Yueqiang Sun, Junming Xia, Xianyi Wang, Xiangguang Meng, Peng Hu, Cong Yin, Guangyuan Tan, Ruhan Wu, Yunlong Du, Xiaofeng Meng   +12 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source