Results 61 to 70 of about 5,105,031 (285)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Variations of the surface characteristics of Ryugu returned samples

Earth, Planets and Space, 2023
Hayabusa2 spacecraft successfully collected rock samples from the surface of C-type near-Earth asteroid 162173 Ryugu through two touchdowns and brought them back to Earth in 2020.
Aiko Nakato, Toru Yada, Masahiro Nishimura, Kasumi Yogata, Akiko Miyazaki, Kana Nagashima, Kentaro Hatakeda, Kazuya Kumagai, Yuya Hitomi, Hiromichi Soejima, Jean-Pierre Bibring, Cedric Pilorget, Vincent Hamm, Rosario Brunetto, Lucie Riu, Lionel Lourit, Damien Loizeau, Tania Le Pivert-Jolivet, Guillaume Lequertier, Aurelie Moussi-Soffys, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Sei-ichiro Watanabe, Yuichi Tsuda   +29 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An Educational Introduction to ITAR and EAR Regarding Pressure Suits and Space Suits

Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Estimation of Mode Transition in a Supersonic Combustor

Journal of Thermal Science and Technology, 2013
A quasi-one dimensional calculation was carried out to figure out supersonic combustor performances. Three flow tubes were considered in the combustor region. Those were an air-flow-tube, a combustion-flow-tube and a fuel-flow-tube.
Junji NODA, Atsuo MURAKAMI, Kenji KUDO, Sadatake TOMIOKA   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Geometric Calibration of the ShadowCam Instrument on the Korea Pathfinder Lunar Orbiter

Journal of Astronomy and Space Sciences
The ShadowCam instrument on the Danuri spacecraft provides high-resolution views of shadowed portions of the Moon, which are illuminated by naturally scattered light from nearby sunlit terrain. The sensitive time-delay integration detector captures high
Emerson Jacob Speyerer, Mark Southwick Robinson, David Carl Humm, Nicholas Michael Estes, Victor Hugo Silva, Robert Vernon Wagner, Prasun Mahanti, Scott Michael Brylow   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source