Results 41 to 50 of about 5,289,200 (291)
A Tool for Parameter-space Explorations
4 pages, 5 figures, CSP 2014 ...
Yohsuke Murase +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Highly explosive basaltic eruptions driven by CO2 exsolution
Mechanisms that drive highly explosive eruptions of low-viscosity magmas, such as at Sunset Crater volcano, remain uncertain. Here, the authors present evidence for an exsolved CO2 phase ~15 km beneath Sunset Crater that was the critical driver of rapid ...
Chelsea M. Allison +2 more
doaj +1 more source
Since the moon’s revolution cycle is exactly the same as its rotation cycle, we can only see the moon always facing Earth in the same direction. Based on the clean particle radiation environment of the moon, a neutral atomic telemetry base station could ...
Li Lu +6 more
doaj +1 more source
Submersible Space Training Suit Preliminary Test Results and Review
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Smith, Cameron, Tresch, Trent
core +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Comparative Analysis of SWH Retrieval Between BDS-R and GPS-R Utilizing FY-3E/GNOS-II Data
High-precision sea surface significant wave height (SWH) data are crucial for advancing oceanic shipping and marine resource development. In this study, we conducted a comparative analysis of parameter sensitivity and accuracy in SWH retrieval between ...
Hui Yu +12 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Human activities affect the Earth’s climate through modifying the composition of the atmosphere, which then creates radiative forcing that drives climate change.
Tianle Yuan +10 more
doaj +1 more source

