Results 51 to 60 of about 287,012 (310)

Particle track imaging simulation and expected outcomes of the Grid-based energetic neutral atom imager (GENA) for the Queqiao-2 mission

Earth, Planets and Space
The two-dimensional Grid-based Energetic Neutral Atom (GENA) imager, carried by the Queqiao-2 relay communication satellite, utilizes two narrow side-by-side multi-pixel shared collimators. In this study, a new set of response functions was developed for
Li Lu, Qing-long Yu, Jin-fa Shao, Yuan Chang, Zhong Xie, Jian Lan, Shuai Jia   +6 more
doaj   +1 more source

Simulation and Validation of Real-Time UAV-Based GNSS-R Altimetry Across Diverse Landforms

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Accurate measurement of land surface elevation is essential for applications, such as terrain mapping, environmental monitoring, and ecological assessment.
Ziyin Xu, Xianyi Wang, Junming Xia, Zhenhe Zhai, Zhuoyan Wang, Cheng Liu, Yusen Tian, Tongsheng Qiu, Yueqiang Sun, Qifei Du, Weihua Bai, Feixiong Huang, Cong Yin   +12 more
doaj   +1 more source

In Situ Optimized Substrate Witness Plates: Ground Truth for Key Processes on the Moon and Other Planets

Earth and Space Science, 2023
Future exploration efforts of the Moon, Mars, and other bodies are poised to focus heavily on persistent and sustainable survey and research efforts, especially given the recent interest in a long‐term sustainable human presence at the Moon. Key to these
Prabal Saxena, Liam S. Morrissey, Rosemary M. Killen, Jason L. McLain, Li Hsia Yeo, Natalie M. Curran, Nithin S. Abraham, Heather V. Graham, Orenthal J. Tucker, Menelaos Sarantos, Aaron B. Regberg, Diane E. Pugel, Andrew W. Needham, Mark Hasegawa, Alfred J. Wong   +14 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Variations of the surface characteristics of Ryugu returned samples

Earth, Planets and Space, 2023
Hayabusa2 spacecraft successfully collected rock samples from the surface of C-type near-Earth asteroid 162173 Ryugu through two touchdowns and brought them back to Earth in 2020.
Aiko Nakato, Toru Yada, Masahiro Nishimura, Kasumi Yogata, Akiko Miyazaki, Kana Nagashima, Kentaro Hatakeda, Kazuya Kumagai, Yuya Hitomi, Hiromichi Soejima, Jean-Pierre Bibring, Cedric Pilorget, Vincent Hamm, Rosario Brunetto, Lucie Riu, Lionel Lourit, Damien Loizeau, Tania Le Pivert-Jolivet, Guillaume Lequertier, Aurelie Moussi-Soffys, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Sei-ichiro Watanabe, Yuichi Tsuda   +29 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Space exploration perception

, 2023
Current research goal is to investigate space exploration perception among general public and students in Europe and USA. People’s attitudes towards space exploration are polarized and ambiguous.
Katarzyna Cieślak, Katarzyna Jasko, Joanna Pyrkosz-Pacyna   +2 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Systemic Evolutionary Chemical Space Exploration For Drug Discovery

, 2021
Chemical space exploration is a major task of the hit-finding process during the pursuit of novel chemical entities. Compared with other screening technologies, computational de novo design has become a popular approach to overcome the limitation of ...
Zhou, Zhou, Xiaoli, Lu, Jun, Yu, Yikai, Wang, Faji, Cai, Shien, Liu, Ning, Xia, Chong, Lu, Xiaoxiao, Zhang, Weihua, Shi   +9 more
core   +1 more source