Results 71 to 80 of about 287,012 (310)

Ground-Based GNSS-R Oil Spill Experiments: Methodology and Results

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Sea surface oil spill detection is of great significance to marine environmental protection and resource development. As an emerging remote sensing technology, Global Navigation Satellite System Reflectometry (GNSS-R) provides a supplementary approach ...
Weihua Bai, Yunlong Du, Cong Yin, Junming Xia, Feixiong Huang, Lichang Duan, Fu Li, Dongmei Song, Yueqiang Sun, Qifei Du, Rui Liu, Guanyi Wang, Xiaofeng Meng   +12 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Probabilistic STA-Bayesian Algorithm for GNSS-R Retrieval of Arctic Soil Freeze–Thaw States

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Soil freeze–thaw (F/T) states are a key indicator of the Arctic climate, highlighting the need for their accurate retrieval. Global navigation satellite system-reflectometry (GNSS-R) offers a promising approach for retrieving soil F/T states, as F/
Xiaofeng Meng, Cong Yin, Junming Xia, Feixiong Huang, Weihua Bai, Qifei Du, Dongmei Song, Lichang Duan, Yunlong Du, Guanyi Wang, Rui Liu   +10 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The evolving role of private actors in space exploration

, 2019
Space activities, and in particular space exploration and human spaceflight, have traditionally been driven by governments procuring space systems from a private industrial base usually through cost-plus contracts involving close scrutiny of operations ...
Iacomino, Clelia
core   +1 more source

Design and Analysis of a Micro–Electro-Mechanical System Thruster for Small Satellites and Low-Thrust Propulsion

Aerospace
As a cost-effective and versatile solution, small satellites are increasingly being considered for space exploration. However, one of the major challenges in deploying small satellites for high total impulse missions, particularly deep space exploration,
Yubin Zhong, Fabrizio Ponti, Francesco Barato, Guojun Xia, Siyu Li, Xiao Zhang, Tao Wu   +6 more
doaj   +1 more source

Effect of Tilted Misalignment on Tribo-Characteristics of High-Speed Ball Bearings in Liquid Hydrogen

Tribology Online, 2010
When radial load applied to the bearings was high, ball excursion occurring in the retainer ball-pockets became large due to ball-speed-variation (BSV). Such BSV was also caused by inclination of the outer race to the shaft (tilted misalignment).
Masataka Nosaka, Satoshi Takada, Makoto Yoshida, Masataka Kikuchi, Takayuki Sudo, Shohei Nakamura   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source