Results 31 to 40 of about 87,273 (315)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A shift in transitional forests of the North American boreal will persist through 2100

Communications Earth & Environment
High northern latitude changes with Arctic amplification across a latitudinal forest gradient suggest a shift towards an increased presence of trees and shrubs.
Paul M. Montesano, Melanie Frost, Jian Li, Mark Carroll, Christopher S. R. Neigh, Matthew J. Macander, Joseph O. Sexton, Gerald V. Frost   +7 more
doaj   +1 more source

Chlorophyll Variability in the Oligotrophic Gyres: Mechanisms, Seasonality and Trends

Frontiers in Marine Science, 2015
A 16-year (1998-2013) analysis of trends and seasonal patterns was conducted for the five subtropical ocean gyres using satellite data: chlorophyll-a (Chl-a) retrievals from ocean color, sea surface temperature (SST), and sea-level anomaly (SLA).
Sergio Romano Signorini, Sergio Romano Signorini, Bryan A. Franz, Charles R. McClain   +3 more
doaj   +1 more source

Storm surge and ponding explain mangrove dieback in southwest Florida following Hurricane Irma

Nature Communications, 2021
Mangroves are adapted to cope with tropical storms, but might be threatened by rising frequency and intensity of these events. Here the authors document one of the largest mangrove diebacks on record following Hurricane Irma in Florida, and show a ...
David Lagomasino, Temilola Fatoyinbo, Edward Castañeda-Moya, Bruce D. Cook, Paul M. Montesano, Christopher S. R. Neigh, Lawrence A. Corp, Lesley E. Ott, Selena Chavez, Douglas C. Morton   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Satellite Observations of Phytoplankton Functional Type Spatial Distributions, Phenology, Diversity, and Ecotones

Frontiers in Marine Science, 2017
Phytoplankton functional diversity plays a key role in structuring the ocean carbon cycle and can be estimated using measurements of phytoplankton functional type (PFT) groupings. Concentrations of 18 phytoplankton pigments were calculated using a linear
Tiffany A. Moisan, Kay M. Rufty, John R. Moisan, Matthew A. Linkswiler   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

In Situ Optimized Substrate Witness Plates: Ground Truth for Key Processes on the Moon and Other Planets

Earth and Space Science, 2023
Future exploration efforts of the Moon, Mars, and other bodies are poised to focus heavily on persistent and sustainable survey and research efforts, especially given the recent interest in a long‐term sustainable human presence at the Moon. Key to these
Prabal Saxena, Liam S. Morrissey, Rosemary M. Killen, Jason L. McLain, Li Hsia Yeo, Natalie M. Curran, Nithin S. Abraham, Heather V. Graham, Orenthal J. Tucker, Menelaos Sarantos, Aaron B. Regberg, Diane E. Pugel, Andrew W. Needham, Mark Hasegawa, Alfred J. Wong   +14 more
doaj   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source