Results 111 to 120 of about 7,555,654 (298)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Possibilities of Proteomics Profiling in Predicting Dysfunction of the Cardiovascular System

Frontiers in Physiology, 2022
V. B. Rusanov, L. Kh. Pastushkova, I. M. Larina, O. I. Orlov   +3 more
doaj   +1 more source

Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes [PDF]

, 2016
Siti Zuraidah Mohamad Zobir, Fazlin Mohd Fauzi, Sonia Liggi, Georgios Drakakis, Xianjun Fu, Tai-Ping Fan, Andreas Bender   +6 more
openalex   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Nature
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1–6.
Eliah G. Overbey, Jangkeun Kim, B. Tierney, Jiwoon Park, Nadia Houerbi, Alexander G Lucaci, Sebastian Garcia Medina, N. Damle, D. Najjar, K. Grigorev, Evan E. Afshin, K. Ryon, K. Sienkiewicz, L. Patras, Remi Klotz, Veronica Ortiz, M. Mackay, A. Schweickart, Christopher R. Chin, Maria A. Sierra, Matias F Valenzuela, E. Dantas, Theodore M. Nelson, Egle Cekanaviciute, Gabriel Deards, J. Foox, S. A. Narayanan, Caleb M. Schmidt, Michael A. Schmidt, Julian C. Schmidt, Sean Mullane, S. S. Tigchelaar, Steven Levitte, Craig D. Westover, Chandrima Bhattacharya, Serena Lucotti, J. Wain Hirschberg, J. Proszynski, Marissa Burke, Ashley S. Kleinman, D. Butler, C. Loy, Omary Mzava, J. Lenz, Doru Paul, C. Mozsary, Lauren M. Sanders, Lynn Taylor, Chintan O. Patel, Sharib A. Khan, Mir Suhail Mohamad, S. G. Byhaqui, Burhan Aslam, Aaron S Gajadhar, Lucy Williamson, Purvi Tandel, Qiu Yang, Jessica Chu, Ryan W Benz, Asim Siddiqui, Daniel Hornburg, Kelly Blease, Juan Moreno, Andrew M. Boddicker, Junhua Zhao, Bryan R. Lajoie, Ryan T. Scott, R. Gilbert, San-huei Lai Polo, Andrew Altomare, S. Kruglyak, Shawn Levy, Ishara S. Ariyapala, Joanne C. Beer, Bingqing Zhang, Briana M. Hudson, Aric Rininger, Sarah E. Church, Afshin Beheshti, George M. Church, Scott M. Smith, Brian E. Crucian, S. Zwart, Irina R Matei, D. Lyden, Francine E. Garrett-Bakelman, J. Krumsiek, Qiuying Chen, Dawson Miller, Joe Shuga, Stephen R. Williams, Corey M. Nemec, Guy Trudel, M. Pelchat, O. Laneuville, Iwijn De Vlaminck, Steven S. Gross, Kelly L. Bolton, Susan M Bailey, Richard D. Granstein, D. Furman, Ari M. Melnick, S. Costes, B. Shirah, Min Yu, Anil S Menon, Jaime Mateus, Cem Meydan, Christopher E. Mason   +108 more
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Space medicine: Hunting for pharmacologist's guide in dealing with drugs in microgravity.

Indian J Pharmacol, 2023
Mahalmani V, Medhi B.
europepmc   +1 more source

In silico exploration of the chemical space of natural compounds from Ayurveda traditional medicine

, 2010
Honey Polur, Kouskoumvekaki, Irene
openalex   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source