Results 91 to 100 of about 953,090 (297)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Space Medicine for the Next Decade as Viewed by the Engineer

, 1959
Presented at the 10th Anniversary Commemoration of the Founding of the Department of Space Medicine, at the School of Aviation Medicine, USAF, Randolph Air Force ...
Haber, Fritz
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Space Medicine of the Next Decade as Viewed by an Astrophysicist

, 1959
Presented at the 10th Anniversary Commemoration of the Founding of the Department of Space Medicine, at the School of Aviation Medicine, USAF, Randolph Air Force ...
Haber, Heinz
core  

Small tissue chips with big opportunities for space medicine. [PDF]

Life Sci Space Res (Amst), 2022
Mu X, He W, Rivera VAM, De Alba RAD, Newman DJ, Zhang YS.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Space Medicine Lab May 1960 (23)

, 1960
A view of an area outside a Space Medicine Lab, May 1960.

core  

Space exploration and lifestyle medicine: a narrative review of its implications for astronaut health and remote Earth-based environments

Frontiers in Physiology
BackgroundSpace exploration, especially long-duration missions such as those to Mars, presents unique and significant challenges to astronaut health. Space medicine, which focuses on maintaining health in extreme environments without access to definitive
Raphaëlle Giguère, Raphaëlle Giguère, Alexandre Marois, Alexandre Marois, Daniel Fortin-Guichard, Jonathan Charest, Jonathan Charest, Julie Rocheleau, Keith Thompson, Michael Stolberg, Philippe St-Martin, Philippe St-Martin, Philippe St-Martin, Audrey Bergouignan, Audrey Bergouignan, Victor Niaussat, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Marie-Pierre Gagnon, Marie-Pierre Gagnon, Marie-Pierre Gagnon, Maxime Sasseville, Maxime Sasseville, Maxime Sasseville, Caroline Rhéaume, Caroline Rhéaume, Caroline Rhéaume   +27 more
doaj   +1 more source

Microgravity and Space Medicine 2.0. [PDF]

Int J Mol Sci, 2022
Grimm D.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source