Results 81 to 90 of about 953,090 (297)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Space Medicine Lab May 1960 (11)
, 1960 A close up view of tubing for experiments within a Space Medicine Lab, May ...
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Space Medicine Lab May 1960 (1)
, 1960 A view of one instrument within the Space Medicine Lab May ...
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Space Medicine of the Next Decade as Viewed by a Physician and Physiologist
, 1950 Presented at the Tenth Anniversary Commemoration of the Founding of the Department of Space Medicine, at the School of Aviation Medicine, USAF, Randolph Air Force ...
Strughold, Hubertus O.
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Benefits of Space Medicine Research for Healthcare on Earth. [PDF]
Cureus, 2023 Shirah B +3 more
europepmc +1 more source
Srpski arhiv za celokupno lekarstvo, 2000 The National Academy of Sciences Committee on Space Biology and Medicine points out that space medicine is unique among space sciences, because in addition to addressing questions of fundamental scientific interest, it must address clinical or human ...
Pool, Sam L.
openaire +3 more sources