Results 61 to 70 of about 926,310 (249)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Parabolic flight induces site specific microbiome changes in women

Frontiers in Microbiology
IntroductionThe vaginal microbiome plays a central role in women’s health by supporting immune function, maintaining mucosal homeostasis, and preventing infections.
Begum Aydogan Mathyk, Begum Aydogan Mathyk, Rohit Shukla, Rohit Shukla, Vivek Kumar, Vivek Kumar, Sidharth P. Mishra, Sidharth P. Mishra, Shawna Pandya, Shawna Pandya, Norah Patten, Kellie Gerardi, Heather Wright Beatty, Aaron H. Persad, Aaron H. Persad, Anthony N. Imudia, Anthony N. Imudia, Hariom Yadav, Hariom Yadav, Shalini Jain, Shalini Jain   +20 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

“Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight”

Frontiers in Immunology
The possibility of impaired cognitive function during deep space flight missions or while living on a Martian colony is a critical point of concern and pleads for further research.
Darcy Tocci, Tomas Ducai, C. A. Barry Stoute, Gabrielle Hopkins, Mohammad G. Sabbir, Afshin Beheshti, Afshin Beheshti, Benedict C. Albensi, Benedict C. Albensi, Benedict C. Albensi   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microgravity and Human Body: Unraveling the Potential Role of Heat-Shock Proteins in Spaceflight and Future Space Missions

Biology
In recent years, the increasing number of long-duration space missions has prompted the scientific community to undertake a more comprehensive examination of the impact of microgravity on the human body during spaceflight.
Olga Maria Manna, Stefano Burgio, Domiziana Picone, Adelaide Carista, Alessandro Pitruzzella, Alberto Fucarino, Fabio Bucchieri   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Use of galvanic vestibular stimulation device as a countermeasure for microgravity effects in spaceflight

Frontiers in Space Technologies
This work discusses the challenges of space exploration, focusing on microgravity-induced physiological changes, particularly those affecting the vestibular system, which significantly alters human performance in space, necessitating effective ...
Enrique Soto, Rosario Vega
doaj   +1 more source