Results 51 to 60 of about 926,310 (249)

Animal‐Assisted Activities With Therapy Dogs in Pediatric Oncology: A Multicenter Survey of the Current Status, Implementation, and Challenges in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Animal‐assisted activities (AAAs) with therapy dogs have shown positive effects on patient well‐being and quality of life in various areas of medicine, including pediatric oncology. However, research on this topic is limited. The aim of this study is to present the current status of AAA in pediatric oncology in Germany, Austria, and
Jan‐Marius Wedig, Birgit Burkhardt, Christof M. Kramm, Kira Ostermann, Sarah C. Goretzki, Uta Dirksen, Nico Kurpiers, Michael M. Schündeln   +7 more
wiley   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

iScience, 2020
Summary: Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts.
Daniela Bezdan, Kirill Grigorev, Cem Meydan, Fanny A. Pelissier Vatter, Michele Cioffi, Varsha Rao, Matthew MacKay, Kiichi Nakahira, Philip Burnham, Ebrahim Afshinnekoo, Craig Westover, Daniel Butler, Chris Mozsary, Timothy Donahoe, Jonathan Foox, Tejaswini Mishra, Serena Lucotti, Brinda K. Rana, Ari M. Melnick, Haiying Zhang, Irina Matei, David Kelsen, Kenneth Yu, David C. Lyden, Lynn Taylor, Susan M. Bailey, Michael P. Snyder, Francine E. Garrett-Bakelman, Stephan Ossowski, Iwijn De Vlaminck, Christopher E. Mason   +30 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Computational modeling of heart failure in microgravity transitions

Frontiers in Physiology
The space tourism industry is growing due to advances in rocket technology. Privatised space travel exposes non-professional astronauts with health profiles comprising underlying conditions to microgravity.
Stefan L. Wilson, Klaus-Martin Schulte, Anne Steins, Russell L. Gruen, Emma M. Tucker, Lex M. van Loon   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Physiologic changes in microgravity may lead to unpredictable effects of spinal anesthesia

Frontiers in Physiology
Regional techniques such as spinal anesthesia may offer advantages over general anesthesia for autonomous medical care during long-duration space missions, yet their behaviour in microgravity remains largely uncharacterised.
Siobhan Wagner, Matthew Turnock
doaj   +1 more source

Is Personalizing Space Medicine, Truly the Future of Space Medicine

Journal of Student Research
Space is a mystery, anything can happen when you are up in space. Astronauts have to be prepared when they travel outside the earth's atmosphere. When going into space many things can go wrong. However, the biggest factor that can go wrong is the astronaut's health. Getting sick in space could be fatal as astronauts have very few options for medication
Shifali Maheshguru, Jothsna Kethar, Dr. Rajagopal Appavu, Ph.d   +2 more
openaire   +1 more source