Results 41 to 50 of about 953,090 (297)

A systematic review of microgravity on reproductive systems: Implications for space biology and human health

iScience
Summary: Microgravity poses risks to mammalian reproductive health by altering gametogenesis, fertilization, and embryonic development. This review summarizes evidence from spaceflight and ground-based microgravity analogs, together with radiation ...
Chun-Fan Lung, Hsuan-Hsuan Lu, Chen-Yen Chung, Pao-Tai Lin, Yi-Chiung Hsu   +4 more
doaj   +1 more source

Optimization of RNA extraction for bacterial whole transcriptome studies of low-biomass samples

iScience, 2022
Summary: We developed a procedure for extracting maximal amounts of high-quality RNA from low-biomass producing (autotrophic) bacteria for experiments where sample volume is limited.
Tom Verbeelen, Rob Van Houdt, Natalie Leys, Ramon Ganigué, Felice Mastroleo   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Extraterrestrial regolith is hemostatic and potentially suitable for hemorrhage control in space

Research and Practice in Thrombosis and Haemostasis
Background: Long-duration space missions beyond low Earth orbit pose increased risks of injury to astronauts. Traumatic hemorrhage will be a cause of preventable death.
Nabil Ali-Mohamad, Ting-Hsuan Wang, Lih Jiin Juang, Nuoya Peng, Massimo F. Cau, Kevin Cannon, Christian J. Kastrup   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The database of peptide medications for human deep-space missions demonstrates the potential for on-demand “Astropharmacy”

Frontiers in Space Technologies
With the advent of long-duration lunar and Martian space missions, health risks will increase significantly as astronauts will be exposed to prolonged periods of reduced gravity, elevated radiation levels, celestial dust, and isolated environments that ...
Rebecca C. Blum, Rebecca C. Blum, Dorra Omrani, Alina Kunitskaya, Alina Kunitskaya, Jessica E. Snyder, Jessica E. Snyder, Cynthia Bui, Philip M. Williams, David J. Loftus, Lynn J. Rothschild, Lynn J. Rothschild, Lynn J. Rothschild   +12 more
doaj   +1 more source

Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice

iScience, 2022
Summary: Human expansion in space is hampered by the physiological risks of spaceflight. The muscle and the liver are among the most affected tissues during spaceflight and their relationships in response to space exposure have never been studied.
Geraldine Vitry, Rebecca Finch, Gavin Mcstay, Afshin Behesti, Sébastien Déjean, Tricia Larose, Virginia Wotring, Willian Abraham da Silveira   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Challenges of Artificial Intelligence in Space Medicine

Space: Science & Technology, 2022
The human body undergoes many changes during long-duration spaceflight including musculoskeletal, visual, and behavioral changes. Several of these microgravity-induced effects serve as potential barriers to future exploration missions.
Ethan Waisberg, Joshua Ong, Phani Paladugu, Sharif Amit Kamran, Nasif Zaman, Andrew G. Lee, Alireza Tavakkoli   +6 more
doaj   +1 more source