Results 41 to 50 of about 173,638,451 (255)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Milnor number equals Tjurina number for functions on space curves [PDF]

, 2001
The equality of the Milnor number and Tjurina number for functions on space curve singularities, as conjectured recently by V. Goryunov, is proved.
David Mond, Mond, D. (David), Straten, Duco van, Duco Van Straten   +3 more
core   +1 more source

A general discrete limit theorem in the space of analytic functions for the Matsumoto zeta-function

, 2021
A modified discrete limit theorem in the sense of the weak convergence of probability measures in the space of analytic functions for the Matsumoto zeta-function is ...
Laurinčikas, Antanas, Kačinskaitė, Roma   +1 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Approximation of Analytic Functions by Shifts of Certain Compositions

Mathematics, 2021
In the paper, we obtain universality theorems for compositions of some classes of operators in multidimensional space of analytic functions with a collection of periodic zeta-functions.
Darius Šiaučiūnas, Raivydas Šimėnas, Monika Tekorė   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analytic Kramer kernels, Lagrange-type interpolation series and de Branges spaces [PDF]

, 2011
The classical Kramer sampling theorem provides a method for obtaining orthogonal sampling formulas. In particular, when the involved kernel is analytic in the sampling parameter it can be stated in an abstract setting of reproducing kernel Hilbert spaces
Hernández-Medina, Miguel A., Miguel A. Hernández-Medina, Antonio G. García, Franciszek Hugon Szafraniec, Hugon Szafraniec, Franciszek, García, Antonio G., Hernández Medina, Miguel Ángel, Szafraniec, Franciszek   +7 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Similarity Invariant and the Commutant of some Multiplication Operators on the Sobolev Disk Algebra

International Journal of Mathematics and Mathematical Sciences, 2012
Let R(𝔻) be the algebra generated in Sobolev space W22(𝔻) by the rational functions with poles outside the unit disk 𝔻¯. In this paper, we study the similarity invariant of the multiplication operators Mg in ℒ(R(𝔻)), when g is univalent analytic on 𝔻 or ...
Ruifang Zhao
doaj   +1 more source