Results 241 to 250 of about 7,633,755 (347)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Turbulent dynamo in the terrestrial magnetosheath. [PDF]

Nat Commun
Vörös Z, Roberts OW, Narita Y, Yordanova E, Nakamura R, Settino A, Schmid D, Volwerk M, Simon Wedlund CL, Varsani A, Sorriso-Valvo L, Bourdin PA, Kis Á.   +12 more
europepmc   +1 more source

Janus Photonic Graphics by Stratified Assembly of Two Distinct Colloids

Advanced Functional Materials, EarlyView.
Double‐sided Janus photonic micropatterns with vivid structural colors are fabricated through a single‐step bottom‐up strategy. Density‐driven stratification and depletion‐mediated crystallization of PMMA and PS binary colloids lead to exclusive lattices on opposite surfaces under centrifugal force.
Young Geon Kim, Yongseok Jung, Sehee Yang, Jiwoo Lee, Shin‐Hyun Kim   +4 more
wiley   +1 more source

Modulational instability and associated multiple dark solitons in relativistically degenerate electron-positron-ion plasmas. [PDF]

Sci Rep
Jahangir R, Masood W, Siddiq M, Batool N, Ullah S, Al-Ghamdi H, Tiofack CGL, El-Tantawy SA.   +7 more
europepmc   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Temporal Effects of Surface Plasmon Polaritons in a Quantum Plasma Slab. [PDF]

Entropy (Basel)
Mendonça JT, Figueiredo JL, Terças H.
europepmc   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Electromagnetic viscosity supported anomalous electric field in the electron diffusion region of collisionless magnetic reconnection. [PDF]

Nat Commun
Zhong ZH, Zhou M, Graham DB, Pang Y, Khotyaintsev YV, Song LJ, Li HM, Tang RX, Deng XH.   +8 more
europepmc   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Numerical study of self-injected electron acceleration in CNT structured targets driven by an 800 nm laser. [PDF]

Sci Rep
Bonţoiu C, Bonatto A, Apsimon Ö, Bandiera L, Cavoto G, Drebot I, Gatti G, Giner-Navarro J, Lei B, Martín-Luna P, Rago I, Rodríguez Pérez J, Nunes BS, Sytov A, Valagiannopoulos C, Welsch CP, Xia G, Zhang J, Resta-López J.   +18 more
europepmc   +1 more source