Results 61 to 70 of about 39,519 (258)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Operational Angular Track Reconstruction in Space Surveillance Radars through an Adaptive Beamforming Approach

Aerospace
In the last few years, many space surveillance initiatives have started to consider the problem represented by resident space object overpopulation. In particular, the European Space Surveillance and Tracking (EUSST) consortium is in charge of providing ...
Marco Felice Montaruli, Maria Alessandra De Luca, Mauro Massari, Germano Bianchi, Alessio Magro   +4 more
doaj   +1 more source

A Multi-Computer System With a Flexible Tool for Efficient Traffic Management

Promet (Zagreb), 2012
In recent years, several computer models have been developedto help traffic engineers understand and solve traffic problems.Although traffic enginee1ing studies continue to be carriedout by manual methods, computer approaches are beingincreasingly ...
Hrvoje Baričević, Antun Kraš
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Advanced Sensor Tasking Strategies for Space Object Cataloging

Aerospace
Space Surveillance and Tracking (SST) plays a crucial role in ensuring space safety. To this end, accurate and numerous observational resources are needed to build and maintain a catalog of space objects. In particular, it is essential to develop optimal
Alessandro Mignocchi, Sebastian Samuele Rizzuto, Alessia De Riz, Marco Felice Montaruli   +3 more
doaj   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Challenges of Space Debris Detection, Tracking, and Monitoring in Near-Earth Orbit: Overview of Current Status and Mitigation Strategies

Information
The accumulation of space debris in near-Earth orbit, particularly in Low Earth Orbit (LEO), poses an increasing threat to satellite operations, communication infrastructures, and long-term space sustainability.
Motti Haridim, Assaf Shaked, Niv Cohen, Jacob Gavan   +3 more
doaj   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Improving Thermospheric Density Predictions in Low‐Earth Orbit With Machine Learning

Space Weather
Thermospheric density is one of the main sources of uncertainty in the estimation of satellites' position and velocity in low‐Earth orbit. This has negative consequences in several space domains, including space traffic management, collision avoidance ...
Giacomo Acciarini, Edward Brown, Tom Berger, Madhulika Guhathakurta, James Parr, Christopher Bridges, Atılım Güneş Baydin   +6 more
doaj   +1 more source