Results 91 to 100 of about 2,159,529 (317)

Recreational use of urban green space in Malaysian cities [PDF]

, 2018
To support green space provision and management, it is important to obtain accurate information about the recreational use of green space, regarding use frequency and types of use, visiting time and duration of visits, but also on how the characteristics
Nillson, Kjell, Abdul Aziz, Nor Akmar, Van den Bosch, Konijnendijk   +2 more
core  

Recursive space: play and creating space [PDF]

, 2012
Space is reconfigured through the participations of both gamers and the game, where game is understood as the programming and hardware of a game technology.
Aylish Wood, Wood, Aylish
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reimagining soil stewardship in the anthropocene: Nature-Positive pathways, pedological perspectives, and land use innovations for soil health and security

Soil Security
Soils underpin terrestrial ecosystems and human well-being, yet they remain highly vulnerable to degradation driven by climate change, unsustainable land use, and intensifying anthropogenic pressures.
Mohamed A.E. AbdelRahman
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Search space pruning and global optimization of multiple gravity assist trajectories with deep space manoeuvres

, 2007
This paper deals with the design of optimal multiple gravity assist trajectories with deep space manoeuvres. A pruning method which considers the sequential nature of the problem is presented.
M. Ceriotti, Becerra, Victor M., Nasuto, S. J., Nasuto, S.J., C. Bombardelli, Anderson, J., Bombardelli, C., Ceriotti, M., Anderson, James D., Becerra, V.M., Nasuto, Slawomir J., V.M. Becerra, Becerra, V. M., S.J. Nasuto, J. Anderson, Bombardelli, Claudio   +15 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reading in public libraries: space, reading activities and user profiles [PDF]

, 2013
This single case research was developed within a public library in Porto, Portugal, Biblioteca Municipal Almeida Garrett. Its main objective was to understand how public library readers interact with space, the Internet technology and reading resources ...
Sequeiros, Paula
core   +1 more source

Traffic-land use compatibility and street design impacts of automated driving in Vienna, Austria

, 2022
The potential rise of automated vehicles (AVs) may significantly impact future traffic volumes, in turn affecting urban street designs and adjacent land use.
Bruck, Emilia, Bruck, Emilia M., Soteropoulos, Aggelos   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source