Results 31 to 40 of about 2,450,404 (270)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Vector Spaces

, 1997
Abstract By the time you reach this point, you will probably have met vector spaces in another course: perhaps matrices, geometry, mechanics, or linear algebra. The treatment here may be somewhat different. A vector space is an algebraic object like a ring or a group, and we will start with a collection of axioms, as we did in the ...
Jin Ho Kwak, Sungpyo Hong
  +4 more sources

Invariant vector fields and groupoids

, 2014
We use the notion of isomorphism between two invariant vector fields to shed new light on the issue of linearization of an invariant vector field near a relative equilibrium.
Lerman, Eugene
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Conservative algebras of $2$-dimensional algebras, II

, 2015
In 1990 Kantor defined the conservative algebra $W(n)$ of all algebras (i.e. bilinear maps) on the $n$-dimensional vector space. If $n>1$, then the algebra $W(n)$ does not belong to any well-known class of algebras (such as associative, Lie, Jordan, or ...
Kaygorodov, Ivan, Volkov, Yury
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Synchronization Stability Analysis of PLL-Based Grid-Connected VSC System by Voltage Space Vectors

CSEE Journal of Power and Energy Systems
This paper focuses on synchronization stability analysis of the power system, in which power electronics are synchronized by the phase-locked loop (PLL).
Huadong Sun, Shuyan Wang, Shiyun Xu, Jingtian Bi, Yiming Wang   +4 more
doaj   +1 more source

alpha-Topological Vector Spaces

Hacettepe Journal of Mathematics and Statistics, 2017
Summary: The notion of \(\alpha\)-topological vector space is introduced and several properties are studied. A~complete comparison between this class and the class of topological vector spaces is presented. In particular, \(\alpha\)-topological vector spaces are shown to be independent from topological vector spaces. Finally, a sufficient condition for
openaire   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source