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Gene and MicroRNA Expression Profile Changes in ISS Crewmembers Blood Samples [PDF]

open access: yes
In space, living organisms are exposed to multiple stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as immune dysfunction.
Berres, Mark   +9 more
core   +1 more source

Isometric training at longer muscle–tendon complex lengths: A potential countermeasure to impaired neuro‐muscle–tendon function during space travel

open access: yesExperimental Physiology, EarlyView.
Abstract Manned space exploration to distant destinations, including Mars, continues to be an aspiration of humankind. Space travel does, however, present many challenges to the body, amongst which adaptation to microgravity is perhaps the largest. For instance, both short and long manned spaceflight missions have shown substantial deleterious effects ...
Gerard McMahon   +2 more
wiley   +1 more source

ATHLETIC: An exoskeleton countermeasure exercise device for resistive and plyometric training in deep‐space missions

open access: yesExperimental Physiology, EarlyView.
Abstract Prolonged exposure to weightlessness leads to loss of muscle and bone mass. Therefore, astronauts on board the International Space Station (ISS) currently perform mandatory daily exercises. ISS missions usually last 6 months, and future missions will become significantly longer when going, for example, to Mars.
Jonas Böcker   +6 more
wiley   +1 more source

Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis

open access: yesnpj Microgravity
Staphylococcus aureus colonizes the nares of approximately 30% of humans, a risk factor for opportunistic infections. To gain insight into S. aureus virulence potential in the spaceflight environment, we analyzed RNA-Seq, cellular proteomics, and ...
Matthew R. Hauserman   +3 more
doaj   +1 more source

Growth hormone secretion during space flight and evaluation of the physiological responses of animals held in the research animal holding facility [PDF]

open access: yes
The spaceflight of the Research Animal Holding Facility (RAHF) on the Space Laboratory 3 (SL 3) provided the opportunity to evaluate the suitability of the RAHF for housing and maintaining experimental animals during spaceflight, and to determine changes
Fast, Thomas N.   +3 more
core   +1 more source

Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness

open access: yesExperimental Physiology, EarlyView.
Abstract Central artery stiffening increases the haemodynamic pulsations transmitted downstream towards target organs, including the brain. While recent evidence suggests that long duration spaceflight is associated with reduced common carotid artery (CCA) distensibility, cerebrovascular pulsatility has not been extensively characterized in astronauts.
Roxanne Fournier   +5 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

open access: yesExperimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

An Overview and Comparison of Aviation and Space Insurance [PDF]

open access: yes, 2019
Commercial aviation and commercial space operations entail significant risk. The very nature of these operations means a mishap can result in significant financial losses.
Suchodolski, Jeanne
core   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

open access: yesExperimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti   +6 more
wiley   +1 more source

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