Results 61 to 70 of about 43,985 (306)

Simulated spaceflight-induced cardiac remodeling is modulated by gut microbial-derived trimethylamine N-oxide

iScience, 2023
Summary: Spaceflight is physically demanding and can negatively affect astronauts’ health. It has been shown that the human gut microbiota and cardiac function are affected by spaceflight and simulated spaceflight.
Zizhong Liu, Gui Luo, Ruikai Du, Guanghan Kan, Xuan Han, Guohui Zhong, Wenjuan Xing, Ying Cui, Weijia Sun, Jianwei Li, Yuheng Li, Dingsheng Zhao, Xinxin Yuan, Xiaoyan Jin, Yanping Han, Huiyuan Sun, Shukuan Ling, Yingxian Li   +17 more
doaj   +1 more source

A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function. [PDF]

, 2019
Intestinal epithelial cell (IEC) junctions constitute a robust barrier to invasion by viruses, bacteria and exposure to ingested agents. Previous studies showed that microgravity compromises the human immune system and increases enteropathogen virulence.
Alvarez, Rocio, Marchelletta, Ronald R, McCole, Declan F, Prisk, G Kim, Sayoc-Becerra, Anica, Stork, Cheryl A   +5 more
core   +1 more source

Is sleep affected after microgravity and hypergravity exposure? A pilot study

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is known to be affected in space travel and in residents of the international space station. But little is known about the direct effects of gravity changes on sleep, if other factors, such as sleep conditions, are kept constant. Here, as a first exploration, we investigated sleep before and after exposure to short bouts of microgravity ...
Barbara Le Roy, Aurore Jouvencel, Anika Friedl‐Werner, Ludmila Renel, Youcef Cherchali, Raouf Osseiran, Ernesto Sanz‐Arigita, Jean‐René Cazalets, Etienne Guillaud, Ellemarije Altena   +9 more
wiley   +1 more source

NASA Space Flight Human-System Standard: enabling human spaceflight missions by supporting astronaut health, safety, and performance [PDF]

, 2023
Sarah D. Childress, Tara C. Williams, David Francisco   +2 more
openalex   +1 more source

Computers in Our Cosmos: Intersections in Geographies of Care, Abolition Geographies and Worker Movements

Transactions of the Institute of British Geographers, EarlyView.
ABSTRACT AI assistants on spacecrafts. Netflix streamed through inter‐planetary communication networks. Colonies on Mars by 2050. While the glamorous public–private ventures into outer space curate discussions on the technical specificities of these proposed projects, this paper reorients discussions on such developments through critical frameworks of ...
Yung Au
wiley   +1 more source

Altered Venous Function during Long-Duration Spaceflights

Frontiers in Physiology, 2017
Aims: Venous adaptation to microgravity, associated with cardiovascular deconditioning, may contribute to orthostatic intolerance following spaceflight.
Jacques-Olivier Fortrat, Ana de Holanda, Kathryn Zuj, Guillemette Gauquelin-Koch, Claude Gharib   +4 more
doaj   +1 more source

Polydopamine-Based Antioxidant Countermeasures Against Spaceflight-Induced Neurodegeneration. [PDF]

Small Sci
Polydopamine nanoparticles (PDNPs) protect neuron‐like cells from microgravity‐ and cosmic radiation‐induced oxidative stress. Through in‐flight and ground‐based experiments, it has been shown that PDNPs preserve neuronal and mitochondrial function, markedly mitigating transcriptional dysregulation caused by spaceflight.
Carmignani A, Marino A, Battaglini M, Belenli Gümüş M, Carrubba E, Balsamo M, Valentini G, Mascetti G, Vukich M, Genchi GG, Ciofani G.   +10 more
europepmc   +2 more sources

Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight [PDF]

, 2019
As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration ...
Antonsen, Erik L., Bayuse, Tina M., Blue, Rebecca S., Chancellor, Jeffery C., Daniels, Vernie R., Wotring, Virginia E.   +5 more
core   +4 more sources

Effect of artificial gravity on calcaneal bone marrow adipose tissue and mineral content in female and male participants in 60 days of bed rest

Experimental Physiology, EarlyView.
Abstract Modulation of bone marrow adipose tissue (BMAT) with prolonged inactivity was reported in haemopoietic but not in non‐haemopoietic bones. This prospective randomized controlled trial submitted 16 men and 8 women to 60 days of 6° head‐down‐tilt bed rest.
Tammy Liu, Gerd Melkus, Tim Ramsay, Alain Berthiaume, Gabriele Armbrecht, Guy Trudel   +5 more
wiley   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source