Results 31 to 40 of about 180,800 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Computational fluid dynamics simulations of solar-assisted, spacer-filled direct contact membrane distillation: Seeking performance improvement

, 2023
Significant downstream performance reduction and concentration polarisation reduce direct contact membrane distillation (DCMD) efficiency. These challenges are not well researched since they are difficult to implement experimentally and numerically ...
Thiel, David V, Ghaffour, Noreddine, Thiel, David V., Ansari, Abolfazl, Helfer, Fernanda, Soukane, Sofiane, Millar, Graeme, Galogahi, Fariba Malekpour   +7 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effect of ligand and shell densities on surface structure of core-shell nanoparticles self-assembled from function-spacer-lipid constructs

, 2023
Biomolecular corona is the major obstacle in clinical translation of nanomedicines. To overcome this problem, comprehensive studies of the processes leading to the formation of a biomolecular corona are required. Since such dynamical studies require high
Anton, Zalygin, Eleonora, Shtykova, Marina , Tretyak, Veronika, Dimitreva, Ivan, Vaskan, Nicolai, Bovin, Maxim, Petoukhov, Vladimir, Oleinikov, Alexander, Tuzikov   +8 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Evaluation of asthma control, parents’ quality of life and preference between AeroChamber Plus and AeroChamber Plus Flow-Vu spacers in young children with asthma

, 2015
Objective: The AeroChamber Plus (AC) valved holding chamber has been enhanced to include the Flow-Vu (FV) inspiratory flow indicator that provides visual inhalation feedback during use. We have investigated if FV alters asthma control and whether parents
Toor, Sophie, Ammari, Wesam G., Stephenson, John, Chrystyn, Henry, Chetcuti, Philip   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Next generation sequencing analysis reveals a relationship between rDNA unit diversity and locus number in Nicotiana diploids

, 2012
Background Tandemly arranged nuclear ribosomal DNA (rDNA), encoding 18S, 5.8S and 26S ribosomal RNA (rRNA), exhibit concerted evolution, a pattern thought to result from the homogenisation of rDNA arrays. However rDNA homogeneity at the single nucleotide
Fulnecek, Jaroslav, Nichols, Richard, Simon Renny-Byfield, Macas Jiří, Kovařík Aleš, Aleš Kovařík, Kovarik, A, Grandbastien Marie-Angele, Andrew Leitch, Renny-Byfield Simon, Leitch Andrew, Kovarik, Ales, Roman Matyášek, Matyasek, R, Macas, Jiri, Macas, J, Richard Nichols, Renny-Byfield, Simon, Nichols Richard, Marie-Angele Grandbastien, Jaroslav Fulneček, Leitch, A, Grandbastien, Marie Angele, Leitch, Andrew, Renny-Byfield, S, Nichols, R, Jiří Macas, Matyášek Roman, Fulneček Jaroslav, Grandbastien, M-A, Fulnecek, J, Matyasek, Roman   +31 more
core   +1 more source

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]

, 2010
Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael, Karl Salzwedel, Salzwedel Karl, Catherine S. Adamson, Eric O. Freed, Sakalian, M, Michael Sakalian, Adamson, Catherine S, Salzwedel, K, Freed Eric O, Freed, E.O., Adamson Catherine S   +11 more
core   +1 more source

Impact of Spacer Cation on the Properties of Two-Dimensional Monolayer Hybrid Halide Perovskites

, 2023
Poor long-term stability of hybrid halide perovskites has severely inhibited their large-scale commercial applications. Recently emerging low-dimensional hybrid halide perovskites have much more enhanced long-term stability, but their wide bandgap and ...
Wei, Zhuang, Tianmin, Wu, Jun, Chen, Tan, Jin, Xian, Chen, Chenchen, Li   +5 more
core   +1 more source