Results 121 to 130 of about 46,073 (264)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

CRISPR spacer profiling and prophage mining reveal diverse bacteriophages associated with <i>Streptococcus Mutans</i>. [PDF]

J Oral Microbiol
Chen X, Zhang M, Yang L, Chen Y, Chi Y, Zhao Y, Ma Z, Li Y, Wang X.   +8 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Fingerprinting organic molecules for the inverse design of two-dimensional hybrid perovskites with target energetics. [PDF]

Sci Adv
Lyu Y, Zhou Y, Zhang Y, Yang Y, Zou B, Weng Q, Xie T, Cazorla C, Hao J, Yin J, Wu T.   +10 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Biomechanical Evaluations of Novel Clip-Type Implants for Cervical Double-Door Laminoplasty, Compared with Conventional Hydroxyapatite Spacers: A Cadaveric Study

Spine Surgery and Related Research
Introduction: Double-door laminoplasty is a common surgical approach; however, implant displacement and hinge fractures can cause lamina closure, leading to unfavorable outcomes.
Takahiro Mui, Sachiko Kawasaki, Hideki Shigematsu, Masaki Ikejiri, Takuya Sada, Apichat Sinthubua, Treerat Gumpangseth, Pasuk Mahakkanukrauh, Yasuhito Tanaka   +8 more
doaj  

On the dynamic caddisfly silk H-fibroin gene: a population study in a net-spinning species. [PDF]

Mol Biol Evol
Stewart RJ, Powell A, Heckenhauer J, Pauls SU, Jijon G, Standring S, Hayashi CY, Baker RH, Frandsen PB.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Single crystal sapphire spacers for in situ angle sensing and rotor stability diagnostics in MAS NMR. [PDF]

Solid State Nucl Magn Reson
Osborn Popp TM, Mullen CG, Brown KL, Dzieminski JB, Scida AM, Tence JA, Drallios K, Perodeau JR, Nieuwkoop AJ.   +8 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source