Results 41 to 50 of about 8,160 (246)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Real analytic Fréchet algebras containing algebras of holomorphic functions [PDF]

, 2015
A class of Fréchet algebras of real analytic functions is constructed, with a weaker condition than complex analyticity. These algebras consist of functions on Stein spaces; a related construction on CR manifolds of a certain type is also given ...
Lawrence, Mark G., Mark G Lawrence
core  

Weighted Banach spaces of harmonic functions [PDF]

, 2014
“The final publication is available at Springer via http://dx.doi.org/10.1007/s13398-012-0109-z."We study Banach spaces of harmonic functions on open sets of or endowed with weighted supremum norms.
Enrique Jordá, Jorda Mora, Enrique, Zarco García, Ana María, Ana María Zarco   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Eigenvalues and dynamical properties of weighted backward shifts on the space of real analytic functions

Studia Mathematica, 2018
Summary: Usually backward shift is neither chaotic nor hypercyclic. We will show that on the space \(\mathscr {A}(\varOmega)\) of real analytic functions on a connected set \({\varOmega}\subseteq \mathbb {R}\) with \(0\in {\varOmega}\), the backward shift operator is chaotic and sequentially hypercyclic.
Domanski, Pawel, Kariksiz, Can Deha
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Analytic Functions on Abstract Wiener Spaces

, 2001
Let (X, H, μ) be a real abstract Wiener space. A new definition of analytic functions on X is introduced, and it is shown that stochastic line integrals of real analytic 1-forms along Brownian motion and solutions to stochastic differential equations ...
Taniguchi, Setsuo
core   +1 more source

Analytic Functions, Cauchy Formula, and Stationary Phase on a Real Abstract Wiener Space

Journal of Functional Analysis, 1997
A new complexification of a real abstract Wiener space will be introduced, and some analogs of the algebra of analytic functions on finite-dimensional Euclidean space will be considered; analytic functions on the original space, their holomorphic prolongation to the complexified space, and holomorphic functions and a Cauchy formula on the complexified ...
Malliavin, Paul, Taniguchi, Setsuo
openaire   +2 more sources