Results 51 to 60 of about 8,825 (229)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Studia Mathematica, 2018 Summary: Usually backward shift is neither chaotic nor hypercyclic. We will show that on the space \(\mathscr {A}(\varOmega)\) of real analytic functions on a connected set \({\varOmega}\subseteq \mathbb {R}\) with \(0\in {\varOmega}\), the backward shift operator is chaotic and sequentially hypercyclic.
Domanski, Pawel, Kariksiz, Can Deha
openaire +2 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Heat and Laplace type equations with complex spatial variables in weighted Bergman spaces
Electronic Journal of Differential Equations, 2017 In a recent book, the authors of this paper have studied the classical heat and Laplace equations with real time variable and complex spatial variable by the semigroup theory methods, under the hypothesis that the boundary function belongs to the ...
Ciprian G. Gal, Sorin G. Gal
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Hadamard type operators on spaces of real analytic functions in several variables
Journal of Functional Analysis, 2015 The paper under review deals with multipliers on the space of real analytic functions of several variables, i.e., linear and continuous operators for which all monomials are eigenvectors. It should be compared with [\textit{M. Langenbruch} and \textit{P. Domański}, Analysis, München 32, No.
Domański, Paweł +2 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Characterization of surjective partial differential operators on spaces of real analytic functions [PDF]
Studia Mathematica, 2004 This important article addresses the following problem: Let \(P(D)\) be a linear partial differential operator with constant coefficients, let \(\Omega\) be an open subset of \(\mathbb R^n\) and let \(A(\Omega)\) denote the space of all complex valued real analytic functions on \(\Omega\).
openaire +1 more source