Results 61 to 70 of about 312,870 (268)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comprehensive Assessments of the Bilal Extended Model with Applications in Mechanical Engineering and Health Insurance

Mathematics
A recent generalized Bilal (G-Bilal) model demonstrates remarkable flexibility in capturing a wide spectrum of failure behaviors, including monotonic and non-monotonic (upside-down bathtub-shaped) hazard patterns, outperforming several existing models ...
Ahmed Elshahhat, Eslam Abdelhakim Seyam
doaj   +1 more source

Influence of Plant Spacing on Growth, Phenology, and Calyx Yield of Roselle (Hibiscus sabdariffa L.) under Subtropical Conditions [PDF]

Madras Agricultural Journal
The experiment investigated the effect of spacing on roselle growth and calyx yield. The experiment consists of seven spacings, viz., 30 cm ?? 30 cm (S1), 60 cm ?? 30 cm (S2), 60 cm ?? 45 cm (S3), 60 cm ?? 60 cm (S4), 90 cm ?? 30 cm (S5), 90 cm ?? 45 cm (
Zahid Hossain Hridoy, Md. Moshiur Rahman, Md. Parvez Anwar, Md. Ismail Hossain, Swapan Kumar Paul   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Performance of cowpea varieties under different phosphorus levels and spacing in Tanzania

Cogent Food & Agriculture
The identification of cowpea varieties that can thrive in P-limited soils and optimal spacing has not yet been addressed in Tanzania. This study evaluated the recently released three cowpea varieties for growth parameters and high yield in different P ...
Mustafa Bakari Mgula, Liberatus Dominick Lyimo, Hilda Gerald Sanga   +2 more
doaj   +1 more source

Spaced cognitive training promotes training transfer

Frontiers in Human Neuroscience, 2014
Cognitive training studies yield wildly inconsistent results. One dimension on which studies vary is the scheduling of training sessions (Morrison & Chein, 2011).
Zuowei eWang, Zuowei eWang, Renlai eZhou, Renlai eZhou, Priti eShah, Priti eShah   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The influence of maternal age, spacing and number of pregnancies on birth weight and height [PDF]

Journal of Kerman University of Medical Sciences, 1995
In this study the relation between maternal age, spacing number of pregnancies and birth weight and height was evaluated 1000 newborns in Fatemeh hospital in Hamedan.
F Zohori, S GHafari
doaj