Results 51 to 60 of about 3,824,074 (333)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Revista Interdisciplinar de Direito, 2021 El ejercicio del derecho de acción se relaciona tradicionalmente con el acceso a la justicia, inicialmente con un sesgo más formalista y limitado con el derecho a obtener una respuesta judicial cognitiva, incluso en sus espacios recursivos.
Adriano Moura da Fonseca Pinto
doaj +1 more source
Magnetometer uses bismuth-selenide [PDF]
, 1972 Characteristics of bismuth-selenide magnetometer are described. Advantages of bismuth-selenide magnetometer over standard magnetometers are stressed. Thermal stability of bismuth-selenide magnetometer is analyzed.
Beale, H., Spain, I. L., Woollman, J. A.
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Boletín de la Sociedad Española de Cerámica y Vidrio, 2012 Ferro Spain SA has tackled the practical viability of tile surfaces decoration by means of applying layers of reduced thickness by means of the use of digital injection technology by inkjet and, specifically, relating to effects and superficial finishes ...
Spain S.A., Ferro
doaj
Processes of Discrimination and Humiliation Experienced by Ecuadorian Immigrant Workers in Spain
Social Inclusion, 2023 The workplace is currently one of the main places of discrimination for socially vulnerable groups such as immigrant workers, who are often required to take on highly stigmatized, menial jobs under supervisors who subject them to daily mistreatment and ...
David Ortega‐Jiménez +3 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Neuroimaging features of immune-related adverse events due to immune checkpoint inhibitor therapy
Insights into ImagingImmune checkpoint inhibitors, a type of intravenous immunotherapy targeting T cells, are being increasingly used in cancer treatment. They work by increasing the immune system’s response to tumour cells, through blockade of inhibitory “checkpoint ...
Arian Lasocki, Lavinia Spain
doaj +1 more source