Results 61 to 70 of about 1,311,589 (257)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Effect of salt seed particle surface area, composition and phase on secondary organic aerosol mass yields in oxidation flow reactors [PDF]
Atmospheric Chemistry and Physics, 2019 Atmospheric particulate water is ubiquitous, affecting particle transport and uptake of gases. Yet, research on the effect of water on secondary organic aerosol (SOA) mass yields is not consistent.
E. Ahlberg +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Observation of Low Temperature Magneto-Mechanic Effects in Crystalline Resonant Phonon Cavities
, 2019 We observe magnetic effects in ultra-high quality factor crystalline quartz Bulk Acoustic Wave resonators at milli-Kelvin temperature. The study reveals existence of hysteresis loops, jumps and memory effects of acoustical resonance frequencies.
Galliou, Serge +2 more
core +1 more source
The H II Region/PDR Connection: Self-Consistent Calculations of Physical Conditions in Star-Forming Regions [PDF]
, 2005 We have performed a series of calculations designed to reproduce infrared diagnostics used to determine physical conditions in star forming regions. We self-consistently calculate the thermal and chemical structure of an H II region and photodissociation
Abel, N. P. +3 more
core +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Impact of Formulation Variables on Meloxicam spanlastics Preparation
Iraqi Journal of Pharmaceutical SciencesSpanlastic is a modern drug delivery that combines vesicular and nanoparticulate characteristics with numerous advantages over topical applied conventional vesicular systems in terms of stablility, penetration flexibility, and targeting.
Lubna Sabri, Mohammed Khalil
doaj +1 more source
Stratospheric ozone trends for 1985–2018: sensitivity to recent large variability [PDF]
Atmospheric Chemistry and Physics, 2019 The Montreal Protocol, and its subsequent amendments, has successfully prevented catastrophic losses of stratospheric ozone, and signs of recovery are now evident.
W. T. Ball +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Development of Vancomycin, a Glycopeptide Antibiotic, in a Suitable Nanoform for Oral Delivery
MoleculesBacterial infections caused by resistant strains have emerged as one of the most significant life-threatening challenges. Developing alternatives to conventional antibiotic formulations is crucial to overcoming these challenges. Vancomycin HCl (VCM) is a
Ali A. Amer +3 more
doaj +1 more source