Results 61 to 70 of about 323,483 (259)

Hemispheric differences in ozone across the stratosphere–troposphere exchange region [PDF]

Atmospheric Chemistry and Physics
Ozone changes in the upper troposphere–lower stratosphere (UTLS) resulting from dynamical and chemical processes strongly affect the atmosphere's radiative forcing. This study analyzed intra- and inter-hemispheric ozone differences in the UTLS within the
R. J. Seguel, R. J. Seguel, C. Opazo, C. Opazo, Y. Cohen, O. R. Cooper, L. Gallardo, L. Gallardo, B.-M. Sinnhuber, F. Obersteiner, A. Zahn, P. Hoor, S. Rohs, A. Marsing   +13 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Investigating the Effect of Mixed Surfactants with Different HLBs on the Properties of Solid Lipid Nanoparticle of Spironolactone

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: This study investigated the effect of different HLBs on these nanoparticles using spironolactone solid lipid nanoparticles.
Zhila Imani, Majid Saeedi, Jafar Akbari, Katayon Morteza Semnani, Zahra Imani   +4 more
doaj  

Research on atmospheric temperature fine measurements from the near surface to 60 km altitude based on an integrated lidar system [PDF]

Atmospheric Measurement Techniques
Accurate measurement of atmospheric temperature profiles from the surface to the stratosphere is crucial for understanding atmospheric dynamics and climate processes.
Z. Wang, T. Guo, T. Guo, X. Li, X. Li, C. Chen, D. Liu, L. Qu, H. Li, H. Li, X. Wang   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Ni cycle in the Southern Ocean: insights from Ni concentrations, isotopes and metagenomics [PDF]

Biogeosciences
Nickel (Ni) is an essential micronutrient for marine microorganisms, involved in enzymes controlling the nitrogen cycle and metabolic responses to oxidative stress.
N. Lemaitre, N. Lemaitre, E. Faure, E. Faure, E. Faure, R. Zamora, C. Archer, M. Sieber, M. Sieber, M. Ellwood, C. Hassler, C. Hassler, Y. Lin, Y. Lin, Y. Lin, N. Cassar, N. Cassar, L. Maignien, L. Maignien, D. Vance   +19 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pengaruh Waktu Reaksi dan Suhu Pada Proses Ozonasi Terhadap Penurunan Warna, COD dan BOD Air Limbah Industri Tekstil

Jurnal Kimia dan Kemasan, 2011
Air limbah industri tekstil pada umumnya bersifat alkali, berbau, berwarna, panas dan mempunyai TSS, BOD dan COD yang tinggi. Oleh karena itu selain berwarna, air limbah industri tekstil mengandung bahan-bahan organik dan logam berat yang berbahaya bagi ...
Emmy Ratnawati
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

pH Gradient-Driven Loading of Doxorubicin into Niosomes: A Comparative Study Using Bromocresol Green as a Visual Indicator

Pharmaceutics
Background: The active (remote) loading of drugs into nanoparticulate systems via the pH gradient technique has been proven highly successful in liposomes, as numerous formulations have reached the market.
Mohammed Altaee, Ahmed Mostafa Faheem, Amal Ali Elkordy   +2 more
doaj   +1 more source