Results 71 to 80 of about 323,483 (259)

Vertically resolved aerosol variability at the Amazon Tall Tower Observatory under wet-season conditions [PDF]

Atmospheric Chemistry and Physics
The wet-season atmosphere in the central Amazon resembles natural conditions with minimal anthropogenic influence, making it one of the rare preindustrial-like continental areas worldwide.
M. A. Franco, M. A. Franco, M. A. Franco, R. Valiati, B. A. Holanda, B. A. Holanda, B. B. Meller, B. B. Meller, L. A. Kremper, L. V. Rizzo, S. Carbone, F. G. Morais, J. P. Nascimento, J. P. Nascimento, M. O. Andreae, M. O. Andreae, M. O. Andreae, M. A. Cecchini, L. A. T. Machado, L. A. T. Machado, M. Ponczek, U. Pöschl, D. Walter, D. Walter, D. Walter, C. Pöhlker, P. Artaxo   +26 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pengaruh Radiasi Berkas Elektron dan Kimia Pada Pembuatan Glukosa dari Tandan Kosong Sawit

Jurnal Kimia dan Kemasan, 2013
Telah dilakukan penelitian pembuatan glukosa dari tandan kosong sawit (TKS) dengan 2 tahap, yaitu perlakuan pendahuluan iradiasi berkas elektron dilanjutkan dengan alkali dan asam, diikuti dengan proses sakarifikasi.
Darsono Darsono, Sugiarto Danu, Made Sumarti Kardha, Harsojo Harsojo   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Composite of Carboxymethyl Cellulose/MXene and Span 60 as Additives to Enhance Tribological Properties of Bio-Lubricants

Lubricants
Bio-lubricants are the future of lubricants as a substitute for mineral lubricants; however, bio-lubricants have drawbacks, such as poor thermal-oxidative stability. In addition, during the friction process, the temperature of the lubricant increases, so
Dedison Gasni, Dieter Rahmadiawan, Ridho Irwansyah, Aldi Em Khalid   +3 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Perolehan Kembali Seng Dari Limbah Industri Galvanis Sebagai Seng Asetat

Jurnal Kimia dan Kemasan, 2014
Seng dross merupakan hasil samping dari industri pelapisan logam (galvanis) dengan proses hot-dip dan mempunyai kandungan seng yang cukup tinggi. Hasil samping ini dapat digunakan sebagai bahan baku seng asetat.
Siti Agustina, Nastiti Siswi Indrasti, Suprihatin Suprihatin, Nurul Taufiqu Rochman   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source