Results 91 to 100 of about 1,479,808 (256)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Effect of Salinity, pH, and Temperature on Stability of Gas Condensate in Water Emulsions Using Different Surfactants [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
Light hydrocarbons in water emulsions are formed in many gas refinery wastewaters, and its stability depends on some parameters such as temperature, pH and salinity.
Hossein Esmaeili, Fereidoon Esmaeilzadeh, Dariush Mowla   +2 more
doaj  

Smokers with a high normal heart rate (80-99/min) found their life span shortened by 13 years

Tobacco Induced Diseases, 2018
Background Not all smokers are alike in their mortality risk. Heart rate is not routinely considered as a CVD or mortality risk when the rate is less than 100/min, and both smokers and doctors are unaware of any risk from normal heart rate.
Chi-Pang Wen, Po-Jung Lu, Shan-Pou Tsai, Jamila Chiu, Min-Kuang Tsai, June-Han Lee, Ta-Chen Su, Christopher Wen   +7 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Rapid communication: Middle Pleistocene Transition as a phenomenon of orbitally enabled sensitivity to initial values [PDF]

Climate of the Past
The Middle Pleistocene Transition (MPT), i.e., the “fast” transition from ∼ 41 to ∼ 100 kyr rhythmicity that occurred about 1 Myr ago, remains one of the most intriguing phenomena of the past climate.
M. Y. Verbitsky, M. Y. Verbitsky, A. W. Omta   +2 more
doaj   +1 more source

Stability of water-in-oil-in-water emulsions formed by membrane emulsification : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Food Technology at Massey University, Palmerston North, New Zealand [PDF]

, 2004
The main objectives of this study were to determine i. The effectiveness of encapsulating whey protein concentrates (WPC) within water-in-oil-in-water multiple emulsions produced by membrane emulsification. ii.
Janardhanan, Jithesh
core  

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Niosomal nanocarriers for gemcitabine in treatment of MDA-MB-231, AsPC-1 and Calu-6 cells: investigations in vitro and in vivo

Heliyon
Gemcitabine (GEM) is a cytotoxic chemotheraputic agent employed for treatment of different cancers. GEM-loaded nanoniosomes were synthesized and characterized to enhance efficacy and weaken its side effects by decreasing half-maximal inhibitory ...
Aliyeh Ranjbar, Mohammadreza Ajdari, Khashayar Karimian, Maryam Karimi, Hossein Heli, Naghmeh Sattarahmady   +5 more
doaj   +1 more source