Results 81 to 90 of about 285,519 (260)

Investigating the Effect of Mixed Surfactants with Different HLBs on the Properties of Solid Lipid Nanoparticle of Spironolactone

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: This study investigated the effect of different HLBs on these nanoparticles using spironolactone solid lipid nanoparticles.
Zhila Imani, Majid Saeedi, Jafar Akbari, Katayon Morteza Semnani, Zahra Imani   +4 more
doaj  

Niosomal nanocarriers for gemcitabine in treatment of MDA-MB-231, AsPC-1 and Calu-6 cells: investigations in vitro and in vivo

Heliyon
Gemcitabine (GEM) is a cytotoxic chemotheraputic agent employed for treatment of different cancers. GEM-loaded nanoniosomes were synthesized and characterized to enhance efficacy and weaken its side effects by decreasing half-maximal inhibitory ...
Aliyeh Ranjbar, Mohammadreza Ajdari, Khashayar Karimian, Maryam Karimi, Hossein Heli, Naghmeh Sattarahmady   +5 more
doaj   +1 more source

Formulation of Span 80 niosomes modified with SDS for lactic acid entrapment

Desalination and Water Treatment, 2015
AbstractThis study examines the effects of different formulation parameters on the physico-chemical properties of niosomes containing Span 80 (sorbitan monooleate), cholesterol and/or SDS (sodium dodecyl sulfate), and lactic acid for the future use of formulated niosomes as lactic acid extraction agents in aqueous solutions.
Roberto Fraile, Ramona M. Geanta, Isabel Escudero, José M. Benito, María O. Ruiz   +4 more
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

How the designed processing parameters affect the liquid mixture density and viscosity of the tretinoin-loaded niosomes at different temperatures?

Heliyon
The current study was conducted to present novel thermophysical data on tretinoin-loaded niosomes paired with a combination of span 60 and tween 80.
Azam Shadloo, Kiana Peyvandi, Abolfazl Shojaeian, Sheida Shariat   +3 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Effect of Tween 80 and Span 80 Surfactants Systems on the Malus domestica Emulsions for Anti-Cutibacterium acnes

Sciences of Pharmacy
Red apple (Malus domestica) extract, rich in hydrophobic quercetin, was formulated into oil-in-water (O/W) emulsion using a 22 factorial design to evaluate Tween 80 (8-10 g) and Span 80 (2-4 g) concentrations, targeting pH (4.5-6.0), transmittance (90-100%), and viscosity (10-2000 cPs). Design-Expert® 13 analysis identified formulations F1, FA, and FAB
Theodorus Handoyo, Juniar Resmi, Rahmi Hutabarat, Yovi Guanse   +3 more
openaire   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source