Results 41 to 50 of about 1,479,808 (256)

Optimizing novasomes: impact of oleic acid and co-surfactant ratio on posaconazole delivery: In vitro & Ex vivo pharmacokinetic study

Journal of Applied Pharmaceutical Research
Background: Posaconazole, currently available as a solid oral dosage form, possesses erratic pharmacokinetics that complicate dosing regimens and increase the risk of adverse effects and drug interactions. Hence, innovative strategies, especially topical
Tushar Rukari, Prashant L Pingale, Chandrashekhar D Upasani   +2 more
doaj   +1 more source

Molecular Dynamics Simulation to Study the Oil/Water Interfacial Behavior of Nanoemulsions Stabilized by Different Emulsifiers [PDF]

Shipin Kexue
To reveal the difference in the oil/water interfacial behavior of nanoemulsions prepared separately with three emulsifiers, octenyl succinic anhydride (OSA)-modified starch, Tween-80/Span-80 (T/S80), and lecithin, this study employed a rheometer and a ...
YANG Yishuang, XIONG Housheng, XIE Xin’an, LI Pan, DU Bing, LI Lu
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Phase Manifestation and Formation of Nanoemulsions Composed of Imidazolium-based Ionic Liquid, Tween 80/Span 80 and Labrafac Lipophile WL 1349

ASEAN Journal on Science and Technology for Development, 2017
onic liquids (ILs) can enhance topical and transdermal delivery, as well as increase the solubility of sparingly soluble drugs. In the present work, pseudo-ternary phase diagrams of emulsions were composed of a mixture of non-ionic surfactants ...
S. H. Ng, P. M. WOI, C. C. ENG
doaj   +1 more source

Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial [PDF]

Avicenna Journal of Phytomedicine, 2019
Objective: Inflammation along with oxidative stress plays an important role in the development, progression, instability and rupture of coronary atherosclerotic plaques.
Amir hooshang Mohammad pour, Mostafa Dastani, Roshanak Salari, Sohrab Radbin, Soghra Mehri, Maryam Ghorbani, Asieh Karimani, Masoumeh Salari   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Heart rate measurement and electrical pulse signal analysis for subjects span of 20–80 years

Journal of Electrical Systems and Information Technology, 2018
The preliminary research constructs the heart beat or pulse measurement for medical science. The electrical pulse signal analysis that supports one significant clinical study.
Neramitr Chirakanphaisarn, Thadsanee Thongkanluang, Yuwathida Chiwpreechar   +2 more
doaj   +1 more source

Large scale optimization of transonic axial compressor rotor blades [PDF]

, 2008
[First Paragraphs] In the present work the Multipoint Approximation Method (MAM) by Toropov et al. (1993) has been applied to the shape optimization of an existing transonic compressor rotor (NASA rotor 37) as a benchmark case.
Polynkin, A., Shahpar, S., Toropov, V.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Values of H_0 from Models of the Gravitational Lens 0957+561 [PDF]

, 1999
The lensed double QSO 0957+561 has a well-measured time delay and hence is useful for a global determination of H0. Uncertainty in the mass distribution of the lens is the largest source of uncertainty in the derived H0.
Angonin-Willaime M.-C., Garrett M. A., Garrett M. A., Gary Bernstein, Ingber L., Kundic T., Patnaik A. R., Philippe Fischer, Refsdal S., Richstone D. O., Schneider P.   +10 more
core   +2 more sources