Results 81 to 90 of about 780,612 (302)

Deflection and frequency monitoring of the Forth Road Bridge, Scotland, by GPS [PDF]

open access: yes, 2012
Permission is granted by ICE Publishing to print one copy for personal use. Any other use of these PDF files is subject to reprint fees. Copyright © 2012 Thomas Telford Ltd.The use of carrier phase kinematic GPS (global positioning system) has evolved ...
Atkins, C   +5 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Practical Guide to Engineering and Construction Contracts

open access: yesAustralasian Journal of Construction Economics and Building, 2010
Book ReviewPractical Guide to Engineering and Construction Contracts Philip Loots and Donald Charrett, CCH Australia Limited, Sydney 2009, 439 pages plus index, ISBN 9781921593529 (hardback) AUD ...
Philip Davenport
doaj   +3 more sources

Teaching innovation and its role crafting the classroom of today and the future

open access: yesJournal of Technology and Science Education, 2011
The Journal of Technology and Science Education (JOTSE) has been created as a contribution to the development and improvement of scientific and technological education by constituting a common space to share experiences to all those who, somehow, are ...
Beatriz Amante García   +1 more
doaj   +1 more source

Space shuttle electrical power generation and reactant supply system [PDF]

open access: yes, 1985
The design philosophy and development experience of fuel cell power generation and cryogenic reactant supply systems are reviewed, beginning with the state of technology at the conclusion of the Apollo Program. Technology advancements span a period of 10
Simon, W. E.
core   +1 more source

Vibrational Modal Frequencies and Shapes of Two-Span Continuous Timber Flooring Systems [PDF]

open access: yes, 2019
Based on classic vibrational bending theory on beams, this paper provides comprehensive analytical formulae for dynamic characteristics of two equal span continuous timber flooring systems, including frequency equations, modal frequencies, and modal ...
Kilpatrick, Tony, Zhang, Binsheng
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated Production of Lobophorin CR4 via Metabolic Engineering and Genome Mining

open access: yesMarine Drugs, 2019
Marine-sourced actinomycete genus Streptomyces continues to be an important source of new natural products. Here we report the complete genome sequence of deep-sea-derived Streptomyces olivaceus SCSIO T05, harboring 37 putative biosynthetic gene clusters
Chunyan Zhang   +3 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

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