Results 41 to 50 of about 187,084,903 (250)
The Edge Metric Dimension of the Comb Product of a Cycle and a Graph with a Dominant Vertex
Electronic Journal of Graph Theory and ApplicationsIn this paper, we determine the edge metric dimension of the comb product of a cycle graph and a simple graph containing a dominant vertex. This result generalizes previous findings on the edge metric dimension of the comb product of a cycle and a ...
Abdilla Nurul Azisah Mn +3 more
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Complete bipartite graph is a totally irregular total graph
Electronic Journal of Graph Theory and Applications, 2021 A graph G is called a totally irregular total k-graph if it has a totally irregular total k-labeling λ : V ∪ E→ 1, 2, ... , k, that is a total labeling such that for any pair of different vertices x and y of G, their weights wt(x) and wt(y) are distinct,
Meilin I. Tilukay +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Directed graph iterated function systems [PDF]
, 2011 This thesis concerns an active research area within fractal geometry. In the first part, in Chapters 2 and 3, for directed graph iterated function systems (IFSs) defined on ℝ, we prove that a class of 2-vertex directed graph IFSs have attractors that ...
Boore, Graeme C.
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On hamiltonicity of 1-tough triangle-free graphs
Electronic Journal of Graph Theory and Applications, 2021 Let ω(G) denote the number of components of a graph G. A connected graph G is said to be 1-tough if ω(G − X)≤|X| for all X ⊆ V(G) with ω(G − X)>1. It is well-known that every hamiltonian graph is 1-tough, but that the reverse statement is not true in ...
Wei Zheng, Hajo Broersma, Ligong Wang
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
, 2009 The discovery of drugs that can effectively treat disease and alleviate pain is one of the core challenges facing modern medicine. The tools and techniques of machine learning have perhaps the greatest potential to provide a fast and efficient route ...
Demco, Anthony A, Demco, Anthony A.
core +1 more source