Results 31 to 40 of about 2,249,082 (272)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
DISCURSOS Y ESTRATEGIAS PARA UN PROYECTO DE ESCUELA COEDUCATIVA EN LA TRANSICIÓN ESPAÑOLA. ALGUNAS FUENTES PARA SU ESTUDIO. [PDF]
Cabás, 2010 EI anáIisis que presento tiene que ver con Ias propuestas educativas que eI movimiento feminista de Ia Transición democrática españoIa vehicuIizó y eIaboró para un cambio en Ia escueIa y en Ia sociedad.
Sanjuán, V. R.
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
La iconicidad de la reduplicación léxica en español [PDF]
Estudios Interlingüísticos, 2019 El objetivo del presente estudio consiste en examinar la motivación icónica de la reduplicación léxica en español. Como la reduplicación en distintas lenguas está asociada al fenómeno de la iconicidad, el presente artículo pretende averiguar si un tipo ...
Ewa Urbaniak
doaj
RIDE, 2019 The project P. S. Post Scriptum (2012–2017) was aimed at the collection, edition, and analysis of Spanish and Portuguese private letters from the 16th to the early 19th century.
Ulrike Henny-Krahmer
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
La especialidad de español como carrera universitaria en China [PDF]
marcoELE. Revista de Didáctica Español Lengua Extranjera, 2014 En la actualidad muchas universidades e instituciones educativas españolas tratan de atraer al cada vez mayor número de estudiantes chinos de español. Sin embargo, lograr tal fin y, por tanto, consolidar la colaboración entre instituciones españolas y ...
Querol Bataller, María
doaj
Cervantes and the Golden Age Theatre: First Attempts Towards a Digital Scholarly Editorial Model
RIDE, 2016 For the first time, La Entretenida offers a digital scholarly edition of a theatrical text written by Miguel de Cervantes. From a scholarly perspective, the edition has a considerable value offering a brief contextualization of the play, a clear set of ...
Susanna Allés Torrent
doaj +1 more source