Results 51 to 60 of about 3,139,206 (305)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Metaphor in Spanish L2 and Heritage Language Learners’ Speech: How Does it Compare?

Darnioji daugiakalbystė, 2019
One way in which language practitioners and researchers have furthered our understanding of heritage language learners’ linguistic abilities has been to compare them to L2 learners.
Tocaimaza-Hatch Cecilia
doaj   +1 more source

Politeness in Ecuadorian Spanish [PDF]

, 1996
This paper examines politeness phenomena in Ecuadorian Spanish as reflected in the language of telephone conversations, and, as such, attempts to add another cultural perspective to the discussion of politeness issues and of Brown and Levinson's (1978 ...
Placencia, Maria Elena
core   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

The Use of Spanish Light Verb Constructions in the Advocate General’s Opinions of the Court of Justice of the European Union

Darnioji daugiakalbystė
Over the past few decades, increasing attention has been devoted towards the study of formulaic language, both in Lithuania and abroad. It is assumed that stable word combinations, rather than single words, are preferred in speaking and translating ...
Serapinienė Gabija
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Comparative Analysis of Contextual Usage of the Lexemes мiръ / миръ / мир and their translations into Spanish

RUDN Journal of Language Studies, Semiotics and Semantics
In the critical literature devoted to the L.N. Tolstoy’s novel «War and Peace», the contradictory contexts of usage of the lexemes мiръ / миръ / мир and their relation to homonymy, were repeatedly discussed.
Marina O. Chichina
doaj   +1 more source

DISCURSOS Y ESTRATEGIAS PARA UN PROYECTO DE ESCUELA COEDUCATIVA EN LA TRANSICIÓN ESPAÑOLA. ALGUNAS FUENTES PARA SU ESTUDIO. [PDF]

Cabás, 2010
EI anáIisis que presento tiene que ver con Ias propuestas educativas que eI movimiento feminista de Ia Transición democrática españoIa vehicuIizó y eIaboró para un cambio en Ia escueIa y en Ia sociedad.
Sanjuán, V. R.
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source