Results 61 to 70 of about 3,114,850 (358)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Spanish Spanish

CIENCIA UNEMI
Resumen En la presente investigación se va analizar el control de convencionalidad, que es un concepto teórico-jurídico desarrollado por la Corte Interamericana de Derechos Humanos (Corte IDH), cuyo objetivo principal es asegurar la conformidad del derecho nacional con el derecho internacional de los derechos humanos.
Venegas Guayasamín, Bryan Andrés, Balladares Sánchez , , Carmen Elizabeth, Borja Roldán, Byron Alejandro, Galarza Castro , Christian Xavier   +3 more
openaire   +3 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

The Use of Spanish Light Verb Constructions in the Advocate General’s Opinions of the Court of Justice of the European Union

Darnioji daugiakalbystė
Over the past few decades, increasing attention has been devoted towards the study of formulaic language, both in Lithuania and abroad. It is assumed that stable word combinations, rather than single words, are preferred in speaking and translating ...
Serapinienė Gabija
doaj   +1 more source

Metaphor in Spanish L2 and Heritage Language Learners’ Speech: How Does it Compare?

Darnioji daugiakalbystė, 2019
One way in which language practitioners and researchers have furthered our understanding of heritage language learners’ linguistic abilities has been to compare them to L2 learners.
Tocaimaza-Hatch Cecilia
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Comparative Analysis of Contextual Usage of the Lexemes мiръ / миръ / мир and their translations into Spanish

RUDN Journal of Language Studies, Semiotics and Semantics
In the critical literature devoted to the L.N. Tolstoy’s novel «War and Peace», the contradictory contexts of usage of the lexemes мiръ / миръ / мир and their relation to homonymy, were repeatedly discussed.
Marina O. Chichina
doaj   +1 more source

DISCURSOS Y ESTRATEGIAS PARA UN PROYECTO DE ESCUELA COEDUCATIVA EN LA TRANSICIÓN ESPAÑOLA. ALGUNAS FUENTES PARA SU ESTUDIO. [PDF]

Cabás, 2010
EI anáIisis que presento tiene que ver con Ias propuestas educativas que eI movimiento feminista de Ia Transición democrática españoIa vehicuIizó y eIaboró para un cambio en Ia escueIa y en Ia sociedad.
Sanjuán, V. R.
doaj   +1 more source

A K-Nearest Neighbors Algorithm in Python for Visualizing the 3D Stratigraphic Architecture of the Llobregat River Delta in NE Spain [PDF]

, 2022
Manuel Bullejos, David Cabezas, Manuél Martı́n-Martı́n, Francisco J. Alcalá   +3 more
openalex   +1 more source