Results 41 to 50 of about 2,720,872 (300)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Historia de las primeras traducciones al español de Madame Bovary (1875-1935) [PDF]

open access: yesÇédille: Revista de Estudios Franceses, 2019
This article documents the history of the first Spanish translations of Madame Bovary in Spain and Latin America over more than half a century: from 1875, when the first version was published in Spanish, until the Spanish Civil War, turning point in the ...
María José Hernández Guerrero
doaj  

Rebels With a Cause in Spanish America [PDF]

open access: yesRechtsgeschichte - Legal History, 2019
Gregorio Salinero, Hombres de mala corte. Desobediencias, procesos políticos y gobierno de Indias en la segunda mitad del siglo XVI (traducción de Manuela Águeda García Garrido), Madrid: Cátedra 2017, 483 p., ISBN 978-84-376-3641 ...
Otto Danwerth
doaj   +1 more source

The First Spanish Short Wave Stations. Development of Radio & Tv Technology [PDF]

open access: yes, 2010
In the thirties in Spain there were three big Short Wave Stations. One, belonging to Transradio Española in Aranjuez, 50 kilometers south of Madrid, which rendered radiotelegraphic services to the Canary Islands, Europe and America. Another, belonging to
Romeo Lopez, Jose M.
core  

The repercussions of the treaties of Utrecht for Spanish colonial trade and the struggle to retain Spanish America

open access: yes, 2017
The Peace of Utrecht created a new geopolitical map for Europe with the territorial breakup of the Hispanic monarchy. This fact, the political and territorial consequences, along with the impact of diplomacy and military operations, has been among the ...
Crespo Solana, Ana
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Crítica literaria y traducción cultural: una problematización del “boom” de la narrativa latinoamericana

open access: yesTransfer, 2017
Bearing in mind the important role of literary mediators –translators, critics, editors, etc,- in building up the world literary space, this study intends to do research on the image of the Spanish America that was discursively built by those mediators ...
Denise Mallmann Vallerius
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

Spanish Relief Committee's correspondence concerning refugees of the Spanish civil war

open access: yes, 1939
Correspondence with Australian Commonwealth Government, Australian League of Nations Union, NSW Council for the Relief of Spanish Distress, United Associations of Women, YMCA, Joyce Metcalf and others, together with copies of minutes of Executive ...
Spanish Relief Committee
core   +1 more source

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