Results 41 to 50 of about 822,235 (306)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2014 Objectius: analitzar la situació de la gestió de projectes com a matèria en els estudis universitaris de grau i postgrau (màster) d'Informació i Documentació a Iberoamèrica (l'Argentina, Bolívia, el Brasil, Colòmbia, Costa Rica, Cuba, l'Equador, el ...
Cobo Serrano, Silvia +1 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Transfer, 2017 Bearing in mind the important role of literary mediators –translators, critics, editors, etc,- in building up the world literary space, this study intends to do research on the image of the Spanish America that was discursively built by those mediators ...
Denise Mallmann Vallerius
doaj +1 more source
Revista de Estudios Latinoamericanos sobre Reducción del Riesgo de Desastres, 2023 The Sendai Framework for Disaster Risk Reduction specifies that international cooperation for developing countries should be significantly improved through adequate and sustainable support that complements the measures taken at the national level for its
José Pastrana Huguet +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
JPhys MaterialsThe surface chemistry and inter-connectivity within perovskite nanocrystals play a critical role in determining the electronic interactions. They manifest in the Coulomb screening of electron–hole correlations and the carrier relaxation dynamics, among ...
Esteban Rojas-Gatjens +7 more
doaj +1 more source
Historia de las primeras traducciones al español de Madame Bovary (1875-1935) [PDF]
Çédille: Revista de Estudios Franceses, 2019 This article documents the history of the first Spanish translations of Madame Bovary in Spain and Latin America over more than half a century: from 1875, when the first version was published in Spanish, until the Spanish Civil War, turning point in the ...
María José Hernández Guerrero
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source