Results 71 to 80 of about 803,749 (360)

Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald   +74 more
wiley   +1 more source

Comentários a um texto de J. C. Garavaglia

open access: yesAlmanack
Resumo Este artigo tece considerações críticas acerca do artigo de Juan Carlos Garavaglia intitulado "Servir al Estado, servir al poder", sobre a burocracia na construção dos Estados nacionais na América hispânica.
José Murilo de Carvalho
doaj   +1 more source

Eldorado Revisited: Spanish Film-makers in Reagan’s America

open access: yesEuropean Journal of American Studies, 2010
In the early 1980s Spanish directors José Luis Borau and Bigas Luna produced two films – 0n the Line and Reborn respectively – that offered a trans-national perspective on American society of the early Reaganite 1980s.
Vicente J. Benet
doaj   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan   +46 more
wiley   +1 more source

Macroeconomic aspects of Spanish American independence : the effects of fiscal and currency fragmentation, 1800s-1860s. [PDF]

open access: yes
Economic historians explaining the divergent economic path in North and South America over time focus on the post-independence period in the former British or Spanish colonies.
Irigoin, Maria Alejandra
core   +3 more sources

UA68/2 Intercambio Internacional, Vol. IV, No. 1 [PDF]

open access: yes, 1981
Newsletter created by WKU Latin American Studies program regarding science, politics and economic advances in Latin America as well as cooperative projects between WKU and universities across Latin America.
WKU Latin American Studies
core   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco   +18 more
wiley   +1 more source

Non-suicidal self-injury in Latin America [PDF]

open access: yes, 2014
Background Non-Suicidal Self-Injury (NSSI) is defined as the intentional direct injury of the own bodily tissue without suicidal intent. In areas with a Caucasian majority population, such as the USA, Canada and Europe, it is a rapidly increasing ...
Silva Thyssen, Laura, Van Camp, Ingrid
core   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu   +9 more
wiley   +1 more source

Neither So Low Nor So Short: Wages and Heights in Bourbon Spanish America from an International Comparative Perspective [PDF]

open access: yes
This paper offers new quantitative evidence on living standards in Bourbon America through the study of wages and heights. Neither were wages low nor were heights short by the international standards of the period.
Héctor García-Montero   +1 more
core  

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