Results 31 to 40 of about 101,679 (296)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Regional Variation in Mood Use in Spanish: A Comparison Among Three Spanish-Speaking Regions
LanguagesThe current investigation, couched within variationist sociolinguistics, has the purpose of advancing knowledge of regional variation in mood use (the subjunctive and indicative contrast) in Spanish.
Silvia Tort-Ranson, Aarnes Gudmestad
doaj +1 more source
A new test for exemplar theory: Varying versus non-varying words in Spanish
Glossa, 2017 We used a Deese-Roediger-McDermott false memory paradigm to compare Spanish words in which the phonetic realization of /s/ can vary (word-medial positions: bu[s]to ~ bu[h]to ‘chest’, word-final positions: remo[s] ~ remo[h] ‘oars’) to words in which it ...
Anne Pycha
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Thematic variation in English and Spanish newspaper genres
, 2013 The CONTRANOT project is financed by the Spanish Ministry of Science and Innovation under R&D Research Projects Programme (reference number FFI2008-03384). Dr.
Moratón Gutiérrez, Lara +5 more
core +1 more source
Historia de una excepción perfecta
Recherches, 2019 In this study, we carry out a detailed analysis of current grammatical variation phenomena related to the Spanish pretérito perfecto compuesto (present perfect) which we consider to be a major grammaticalization process, as we will show.
Carlos Soler Montes
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Métricas del ritmo aplicadas al estudio dialectológico del español
Estudios de Fonética Experimental, 2022 This paper reviews previous studies about dialectal variation of rhythm in Spanish and aims to analyse possible differences among Spanish spoken in Andalusia, Madrid, and Galicia.
doaj
AN EXPERIMENTAL INVESTIGATION OF VARIATION IN SPANISH DIMINUTIVES.
Dialectologia, 2019 In an online survey, 656 Spanish speakers from 21 countries were asked to select between the long and short diminutive forms of 100 base words (e.g. novio > novito, noviecito). The influence of the base word, the base word’s frequency, and the country of origin, gender, age, and educational level of the speakers were assessed.
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source