Results 171 to 180 of about 227,714 (275)

Deciphering Cell Type Abundance in Proteomics Data Through Graph Neural Networks

open access: yesAdvanced Science, EarlyView.
GraphDEC constructs pseudo bulk reference data using a mixup strategy, then learns low dimensional representations via autoencoders to model intra and inter dataset relationships. These are processed through a multi view adaptive neighborhood aware GNN, integrating reference, target, and joint graphs.
Zhiming Dai   +7 more
wiley   +1 more source

Blockchain‐Empowered H‐CPS Architecture for Smart Agriculture

open access: yesAdvanced Science, EarlyView.
This article reviews the current system architectures for smart agriculture and proposes a blockchain‐empowered hierarchical cyber‐physical system (H‐CPS) framework. It discusses the challenges and outlines future research directions, including the use of semantic blockchain to handle complex data and models.
Xiaoding Wang   +8 more
wiley   +1 more source

Communication-optimal parallel minimum spanning tree algorithms (extended abstract) [PDF]

open access: bronze, 1998
Micah Adler   +4 more
openalex   +1 more source

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

open access: yesAdvanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia   +39 more
wiley   +1 more source

CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy

open access: yesAdvanced Science, EarlyView.
CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan   +3 more
wiley   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang   +9 more
wiley   +1 more source

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