Results 101 to 110 of about 22,630 (210)
ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn +10 more
wiley +1 more source
Microglia‐derived migrasomes induce vascular endothelial pyroptosis through C1qc delivery, uncovering a novel mechanism of blood–brain barrier (BBB) disruption after intracerebral haemorrhage (ICH) and proposing a novel therapeutic strategy targeting extracellular vesicles (EVs).
Mengyuan Li +17 more
wiley +1 more source
Heather Joseph, The Scholarly Publishing and Academic Resources Coalition: An evolving agenda, C&RL News, February 2006. Heather Joseph is the executive director of SPARC. Excerpt: Update. Also see Heather's presentation at the UBC Library / SLAIS Colloquium, University of British Columbia Library, SPARC Futures : an evolving agenda.
openaire +1 more source
Abstract Objectives Exclusive enteral nutrition (EEN) is the first‐line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti‐inflammatory effects of EEN, studying the nutritional composition and transforming growth factor‐β (TGF‐β) effects, in ...
Kawthar Boumessid +6 more
wiley +1 more source
Plasma extracellular vesicles (EVs) from individuals with latent (LTB) or active tuberculosis (ATB) exhibit distinct proteomic compositions, reflecting the underlying immunometabolic states of each phase. In LTB, EVs are enriched in proteins associated with tissue remodeling and lipid metabolism, including TGFβ, APOA1, and APOE, which may participate ...
Eliud S.‐Peregrino +13 more
wiley +1 more source
ZNF865 (BLST) a Novel Regulator of DNA Damage and Cell Senescence in Back Pain
ZNF865 (BLST) has previously been classified as part of the “unknome”, but here in the context of back pain, we demonstrate the first functional characterization of ZNF865. We demonstrate that it regulates genomic stability and subsequent senescence, and that downregulation in the intervertebral disc leads to pain behavior in rodent models.
Christian Lewis +12 more
wiley +1 more source
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
wiley +1 more source
Landscape Mapping Reveals Depth‐Dependent Regional Heterogeneity in Soil Microbial Diversity
ABSTRACT Aim To identify microbial hotspots and investigate the spatial distribution and assembly mechanisms of soil bacterial and archaeal communities across a coastal ecosystem, and to assess implications for biodiversity conservation and sustainable land management. Location Yellow River Delta, China (YRD, ~13,680 km2 coastal plain). Methods A total
Xiongfeng Du +18 more
wiley +1 more source
Background Secreted protein acidic and rich in cysteine (SPARC) has been shown to modulate aggressive behavior in several benign and malignant tumors.
Sopee Poomsawat +4 more
doaj +1 more source

