Results 101 to 110 of about 1,593 (185)
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Spectroscopic Confirmation of Two Massive Red-sequence-selected Galaxy Clusters at Z ~ Approximately Equal to 1.2 in the Sparcs-North Cluster Survey [PDF]
The Spitzer Adaptation of the Red-sequence Cluster Survey (SpARCS) is a deep z -band imaging survey covering the Spitzer SWIRE Legacy fields designed to create the first large homogeneously-selected sample of massive clusters at z > 1 using an infrared ...
Muzzin, Adam +12 more
core
Efficiency of Machine Learning Methods in Information Security Audit Tasks: A Comparative Analysis
Machine learning methods enable accurate identification of processor instruction architectures from byte‐frequency characteristics of executable files. Among the evaluated models, Linear SVC achieved the highest classification performance, demonstrating the potential of AI‐driven approaches for automated information security auditing and digital ...
Z. B. Mukhtarova +5 more
wiley +1 more source
Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian +3 more
wiley +1 more source
Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles
ABSTRACT Background Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in
Jeremy B. Ducharme +6 more
wiley +1 more source
Which came first, the cluster or the early-type galaxy?
The association between galaxy clusters and early-type galaxies has existed for more than half the history of the Universe, and both stellar mass and environment are known to be correlated with color, morphology, and star formation rates of galaxies ...
Muzzin, Adam +19 more
core +1 more source
ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn +10 more
wiley +1 more source
ABSTRACT Lethal prostate cancer (PCa) is dominated by treatment‐refractory progression in bone. In this study, we used plasma‐derived extracellular vesicles (EVs) for monitoring the tumour and therapy‐induced changes in the bone tumour microenvironment (bone‐TME) in men with bone metastatic PCa (M1b PCa).
Emanuela Gentile +11 more
wiley +1 more source
TRANSFORMATION OF URBAN SPACE IN LVIV IN THE CONTEXT OF CALCULATING CO₂ EMISSIONS FROM TRANSPORT
The article analyses a comprehensive approach used by Lviv to assess and map CO₂ emissions from transport within the city’s initiative to curb emissions and improve the urban environment. As early as 2019, the city of Lviv began exploring the possibility
Yurii POLIANSKYI, Natalia BLAZHKO
doaj +1 more source

