Results 51 to 60 of about 1,820,497 (245)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Assigning Spare Parts Management Decision-Making Strategies: A Holistic Portfolio Classification Methodology

Applied Sciences
Maintenance organizations face growing volumes of spare parts, requiring robust classification methodologies to support decision-making. Practitioners continue to rely on simple and single-criterion-specialized methodologies, while research advances ...
Simon Klarskov Didriksen, Kristoffer Wernblad Sigsgaard, Niels Henrik Mortensen, Christian Brunbjerg Jespersen   +3 more
doaj   +1 more source

Manufacturing of speed reducer bars (break discs and bumzes) for vehicles and tractors using local raw materials [PDF]

مجلة التربية والعلم, 2005
Phenol-formaldehyde , Asbestos and Rubber blend was prepared and used as speed reducer bars ( brake-discs and bunzes) alternative to the imported one. we also succeed to prepare an asbestos and novolac blend and used as car brake bunzes.
Mohammed Al Ajili, Jamal Abbas
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Simulation of dynamics behaviors for shipping equipment support with system dynamics analysis approach

Journal of Industrial Engineering and Management, 2015
Purpose: The exactly and precisely supply of carrying spare parts has a crucial impact on support and could improve the performance of equipment. Spare parts support is the crux work which will be limited by spare parts allocation and support cost input.
Yang Song, Jian-hua Yang
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Vehicle reliability impact on the formation of the need for spare parts using the example of KAMAZ-54901

Архитектура, строительство, транспорт
The cost associated with the procurement and storage of spare parts accounts for almost a third of the overall structure of automotive transport operating expenses.
Yu. D. Ishkin
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Planejamento operacional de cadeias de suprimento de peças de reposição integrado com sistemas inteligentes de manutenção [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2014A falta de peças de reposição e a consequente ineficiência da manutenção acarretam baixa ...
Israel, Eduardo Francisco
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source