Results 61 to 70 of about 1,820,497 (245)

Spare Part Replenishment Strategy for Electronic Product Based on Model Predictive Control

open access: yesComplex System Modeling and Simulation
After-sale service plays an essential role in the electronics retail industry, where providers must supply the required repair parts to consumers during the product warranty period.
Xingchang Fu   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

On how the acquisition of recoverable parts influences the profitability of spare parts management for durables [PDF]

open access: yes
In the management of spare parts for durables OEMs often face a sharp decline in sales of spare parts when the warranty period of their products ends. One reason for this effect is given by the high profitability of the after sales market which attracts ...
Rainer Kleber   +2 more
core  

Maintenance Spare Parts Prediction Based on Multilevel Migration Learning CNN-ISE-Attention-BiLSTM

open access: yesIEEE Access
Scientific and accurate prediction of the consumption of equipment maintenance spare parts is crucial to improve the efficiency of equipment failure disposal and enhance the competitiveness of enterprises.
Zhiqiang Cui   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Dynamic buy-back for product recovery in end-of-life spare parts procurement [PDF]

open access: yes
The efficient supply of spare parts is of prime concern for OEMs. Next to the traditional spare parts sources in form of final order and remanufacturing, the option to buy back broken products prevents the OEM from fulfilling his spare parts availability
Tobias Schulz   +2 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

An Advanced Heuristic for Multiple-Option Spare Parts Procurement after End-of-Production [PDF]

open access: yes
After-sales service is a major profit generator for more and more OEMs in industries with durable products. Successful engagement in after-sales service improves customer loyalty and allows for competitive differentiation through superior service like an
Rainer Kleber, Karl Inderfurth
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Optimise initial spare parts inventories: an analysis and improvement of an electronic decision tool. [PDF]

open access: yes
Control of spare parts is very difficult as demands can be very low (once in a few years is no exception), while the consequences of a stockout can be severe.
Dekker, R.   +3 more
core  

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