Results 31 to 40 of about 504,110 (280)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

‘Food is life’: Documenting the politics of food in Melanesia

open access: yesPacific Journalism Review, 2015
In this article, I discuss two recent examples of women’s filmmaking in Melanesia. The documentaries are Tanah Mama (2014), focused on West Papua and Café Niugini (2015), set in Papua New Guinea.
Ceridwen Spark
doaj   +1 more source

Beyond the Unitary State: Multi-Level Governance, Politics, and Cross-Cultural Perspectives on Animal Welfare

open access: yesAnimals, 2023
It is argued that extant cross-cultural research on animal welfare often overlooks or gives insufficient attention to new governance theory, civil society, politics, and the realities of devolved or (quasi-)federal, multi-level governance in the modern ...
Paul Chaney   +2 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Muriel Spark and Africa [PDF]

open access: yes, 2018
Muriel Spark’s centenary year has offered opportunities to explore elements of her writing that deserve wider attention. Her time in Africa is vital in this respect.
Maley, Willy
core  

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman   +8 more
wiley   +1 more source

Piloting a data dashboard to support data-informed health promotion in secondary schools: qualitative analysis of stakeholder interviews

open access: yesBMC Public Health
Background Schools are called upon to use data-informed practice to support student health and well-being. However, they face implementation challenges including data accessibility and literacy. Data dashboards offer a method to address these challenges,
J. Van Godwin   +11 more
doaj   +1 more source

An Analysis of the Combustion Behavior of Ethanol, Butanol, Iso-Octane, Gasoline, and Methane in a Direct-Injection Spark-Ignition Research Engine [PDF]

open access: yes, 2012
Future automotive fuels are expected to contain significant quantities of bio-components. This poses a great challenge to the designers of novel low-CO2 internal combustion engines because biofuels have very different properties to those of most typical ...
Aleiferis, PG   +2 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul   +13 more
wiley   +1 more source

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