Results 21 to 30 of about 504,110 (280)

Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

Frontiers in Immunology
BackgroundIntravitreal delivery of adeno-associated virus (AAV) vectors offers a promising, minimally invasive strategy for retinal gene therapy, but remains limited by dose-dependent intraocular inflammation. Corticosteroid therapy, the current standard
Helena Costa-Verdera, Helena Costa-Verdera, Deepa Jamwal, Emily Fabyanic, Ariel Hippen, Madeleine Salvatore, Aiping Du, Anna Majowicz, David Markusic, Jon E. Chatterton, Virginia Haurigot, Klaudia Kuranda   +11 more
doaj   +1 more source

Electronic conduction in La-based perovskite-type oxides

Science and Technology of Advanced Materials, 2015
A systematic study of La-based perovskite-type oxides from the viewpoint of their electronic conduction properties was performed. LaCo0.5Ni0.5O3±δ was found to be a promising candidate as a replacement for standard metals used in oxide electrodes and ...
Hisashi Kozuka, Kazushige Ohbayashi, Kunihito Koumoto   +2 more
doaj   +1 more source

Direct Ink Writing Technology (3D Printing) of Graphene-Based Ceramic Nanocomposites: A Review

Nanomaterials, 2020
In the present work, the state of the art of the most common additive manufacturing (AM) technologies used for the manufacturing of complex shape structures of graphene-based ceramic nanocomposites, ceramic and graphene-based parts is explained.
Nestor Washington Solís Pinargote, Anton Smirnov, Nikita Peretyagin, Anton Seleznev, Pavel Peretyagin   +4 more
doaj   +1 more source

Effect of Milling Conditions on the Microstructural Design in Aluminum Based Alloy Fabricated by SPS

Metals, 2019
In this work, aluminum-based alloys were mechanically alloyed by various doping elements followed by spark plasma sintering. Three different mixing methods were studied. First, all elemental powders were mixed for 24 h. In the second and the third method,
Anton Smirnov, Ekaterina Kuznetsova, Yuri Pristinskiy, Pavel Podrabinnik, Alexander Mironov, Iosif Gershman, Pavel Peretyagin   +6 more
doaj   +1 more source

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Method and device for detection of a substance [PDF]

, 1982
A device is disclosed in which a discharge grid is provided that has a sufficiently high voltage potential across its grid electrodes so that a substance with predetermined characteristics causes an electric spark discharge to occur between electrodes ...
Yang, L. C.
core   +1 more source

Superconductivity induced by spark erosion in ZrZn2

, 2005
We show that the superconductivity observed recently in the weak itinerant ferromagnet ZrZn2 [C. Pfleiderer et al., Nature (London) 412, 58 (2001)] is due to remnants of a superconducting layer induced by spark erosion.
Bernhoeft, N. R., Hayden, S. M., Kimura, N., Lohneysen, H. v., Pfleiderer, C., Saxena, S. S., Smith, R. P., Uhlarz, M., Vollmer, R., Yates, S. J. C., Yelland, E. A.   +10 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

A novel transcutaneous auricular neurostimulation electrode configuration for treatment of heavy menstrual bleeding: an open-label trial

Bioelectronic Medicine
Background Electrical stimulation of the cervical vagus nerve reduces traumatic blood loss in models of soft tissue injury. This pathway, termed the neural tourniquet, can be accessed with a transcutaneous auricular neurostimulation (tAN) targeting vagus
Christopher J. Czura, Angela C. Weyand, Maureen K. Baldwin, Michael Recht, Caroline G. Benner, Kimiko Harada, Brooke L. Wade, Meghan Luellen, Michael J. Darrow, Melanie A. McWade, Alejandro Covalin, Navid Khodaparast   +11 more
doaj   +1 more source

Inhibition of IFNAR-JAK signaling enhances tolerability and transgene expression of systemic non-viral DNA delivery

Molecular Therapy: Nucleic Acids
Lipid nanoparticles (LNPs) have demonstrated significant therapeutic value for non-viral delivery of mRNA and siRNA. While there is considerable interest in utilizing LNPs for delivering DNA (DNA-LNPs) to address a broad range of genetic disorders, acute
Sujata Senapati, Thais B. Bertolini, Michael A. Minnier, Mustafa N. Yazicioglu, David M. Markusic, Rui Zhang, Joan Wicks, Ali Nahvi, Roland W. Herzog, Matthew C. Walsh, Pedro J. Cejas, Sean M. Armour   +11 more
doaj   +1 more source