Results 1 to 10 of about 158,405 (292)

Evaluating the effectiveness and impact of the ‘HSE Spark’ Innovation Programme: a qualitative study protocol [PDF]

BMJ Open
Introduction According to the WHO, healthcare in Europe requires ‘systemic change through innovation’ if it is to respond to the demographic, epidemiological, environmental and technological challenges the region is facing.
Michelle Howard, Linda Ryan, Jared Gormly, Threase Kessie, Caitriona Heffernan, Laney Hyland Reilly   +5 more
doaj   +2 more sources

Physicochemical Properties of Bis(fluorosulfonyl)amide-Based Ionic Liquids Mixed with Mg and Sr Doped Cubic Li7La3Zr2O12 Powder

Electrochemistry, 2022
Physicochemical properties of bis(fluorosulfonyl)amide anion-based ionic liquids (ILs) adsorbed on solid oxide electrolyte powder of cubic Li7La3Zr2O12 (LLZ) partially substituted by Mg and Sr were evaluated.
Yuu WATANABE, Yuki TAKEUCHI, Masato TAKI, Hidetoshi MIZUTANI, Masato IWASAKI   +4 more
doaj   +1 more source

Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates

Nature Communications, 2021
Pompe disease is currently treated with enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase (GAA). Here, the authors show hepatic-directed gene therapy with AAV vectors enhances GAA bioavailability compared with ERT, resulting ...
Helena Costa-Verdera, Fanny Collaud, Christopher R. Riling, Pauline Sellier, Jayme M. L. Nordin, G. Michael Preston, Umut Cagin, Julien Fabregue, Simon Barral, Maryse Moya-Nilges, Jacomina Krijnse-Locker, Laetitia van Wittenberghe, Natalie Daniele, Bernard Gjata, Jeremie Cosette, Catalina Abad, Marcelo Simon-Sola, Severine Charles, Mathew Li, Marco Crosariol, Tom Antrilli, William J. Quinn, David A. Gross, Olivier Boyer, Xavier M. Anguela, Sean M. Armour, Pasqualina Colella, Giuseppe Ronzitti, Federico Mingozzi   +28 more
doaj   +1 more source

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

Frontiers in Immunology, 2022
AAV gene transfer is a promising treatment for many patients with life-threatening genetic diseases. However, host immune response to the vector poses a significant challenge for the durability and safety of AAV-mediated gene therapy.
Corinne J. Smith, Nikki Ross, Ali Kamal, Kevin Y. Kim, Elizabeth Kropf, Pascal Deschatelets, Cedric Francois, William J. Quinn, Inderpal Singh, Anna Majowicz, Federico Mingozzi, Klaudia Kuranda   +11 more
doaj   +1 more source

Delivering transcutaneous auricular neurostimulation (tAN) to improve symptoms associated with opioid withdrawal: results from a prospective clinical trial

Bioelectronic Medicine, 2022
Background As pharmacological treatments are the primary option for opioid use disorder, neuromodulation has recently demonstrated efficacy in managing opioid withdrawal syndrome (OWS).
Carlos F. Tirado, Stephanie N. Washburn, Alejandro Covalin, Caroline Hedenberg, Heather Vanderpool, Caroline Benner, Daniel P. Powell, Melanie A. McWade, Navid Khodaparast   +8 more
doaj   +1 more source

Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation

Molecular Therapy: Methods & Clinical Development, 2023
Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield a mixture of capsids largely devoid of the transgene (empty capsid) compared with the desired ...
Ohnmar Khanal, Vijesh Kumar, Mi Jin
doaj   +1 more source

Barriers to translational research in Windsor Ontario: a survey of clinical care providers and health researchers

Journal of Translational Medicine, 2021
Background Translational research is an ideology focussed on streamlining the transition of novel research into clinical practice to ultimately benefit populations.
Justin B. Senecal, Karen Metcalfe, Kaila Wilson, Indryas Woldie, Lisa A. Porter   +4 more
doaj   +1 more source

Decarbonization Analysis for Thermal Generation and Regionally Integrated Large-Scale Renewables Based on Minutely Optimal Dispatch with a Kentucky Case Study

Energies, 2023
Decarbonization of existing electricity generation portfolios with large-scale renewable resources, such as wind and solar photo-voltaic (PV) facilities, is important for a transition to a sustainable energy future.
Donovin D. Lewis, Aron Patrick, Evan S. Jones, Rosemary E. Alden, Abdullah Al Hadi, Malcolm D. McCulloch, Dan M. Ionel   +6 more
doaj   +1 more source

Artificial Intelligence Method for the Forecast and Separation of Total and HVAC Loads With Application to Energy Management of Smart and NZE Homes

IEEE Access, 2021
Separating the HVAC energy use from the total residential load can be used to improve energy usage monitoring and to enhance the house energy management systems (HEMS) for existing houses that do not have dedicated HVAC circuits.
Rosemary E. Alden, Huangjie Gong, Evan S. Jones, Cristinel Ababei, Dan M. Ionel   +4 more
doaj   +1 more source

Preclinical assessment of an optimized AAV-FVIII vector in mice and non-human primates for the treatment of hemophilia A

Molecular Therapy: Methods & Clinical Development, 2022
Extensive clinical data from liver-mediated gene therapy trials have shown that dose-dependent immune responses against the vector capsid may impair or even preclude transgene expression if not managed successfully with prompt immune suppression.
Liron Elkouby, Sean M. Armour, Raffaella Toso, Marti DiPietro, Robert J. Davidson, Giang N. Nguyen, Mallory Willet, Stephanie Kutza, Joseph Silverberg, Jennifer Frick, Marco Crosariol, Yuhuan Wang, Chuansong Wang, Katherine A. High, Denise E. Sabatino, Xavier M. Anguela   +15 more
doaj   +1 more source