Results 61 to 70 of about 55,467 (261)

AI can outperform humans in predicting correlations between personality items

Communications Psychology
We assess the abilities of both specialized deep neural networks, such as PersonalityMap, and general LLMs, including GPT-4o and Claude 3 Opus, in understanding human personality by predicting correlations between personality questionnaire items.
Philipp Schoenegger, Spencer Greenberg, Alexander Grishin, Joshua Lewis, Lucius Caviola   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Clinical applications of transcutaneous auricular neurostimulation for opioid use disorder and pain

Brain Stimulation, 2023
Navid Khodaparast, Melanie McWade, Caroline Benner, Carlos Tirado, Bashar Badran, Dorothea Jenkins, Venkat Kakkilaya, Alta DeRoo, Phillip Moore, Alejandro Covalin   +9 more
doaj   +1 more source

Prioritization approaches in the development of health practice guidelines: a systematic review

BMC Health Services Research, 2019
Background Given the considerable efforts and resources required to develop practice guidelines, developers need to prioritize what topics and questions to address.
Amena El-Harakeh, Rami Z. Morsi, Racha Fadlallah, Lama Bou-Karroum, Tamara Lotfi, Elie A. Akl   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Fractal Dimension Distributions of Resting-State Electroencephalography (EEG) Improve Detection of Dementia and Alzheimer’s Disease Compared to Traditional Fractal Analysis

Clinical and Translational Neuroscience
Across many resting-state electroencephalography (EEG) studies, dementia is associated with changes to the power spectrum and fractal dimension. Here, we describe a novel method to examine changes in the fractal dimension over time and within frequency ...
Keith J. Yoder, Geoffrey Brookshire, Ryan M. Glatt, David A. Merrill, Spencer Gerrol, Colin Quirk, Ché Lucero   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Two-Level Multi-Objective Design Optimization Including Torque Ripple Minimization for Stator Excited Synchronous and Flux Switching Machines

IEEE Access
Electric machine performance can be enhanced through torque ripple mitigation, which reduces mechanical vibrations and improves system stability and operation.
Ali Mohammadi, Oluwaseun A. Badewa, Yaser Chulaee, Dan M. Ionel   +3 more
doaj   +1 more source